小动物人工耳蜗植入的微焦X线影像研究  

Micro-focus X-ray for cochlear implantation research on small animals

作　　者：卢伟[1,2] 徐瑾 

机构地区：[1]郑州大学附属第一医院耳鼻咽喉科,450052 [2]Bionic Ear Institute Melbourne Australia [3]Co-operative Research Centre for Cochlear Implant and Hearing Aid Innovation Melbourne Australia [4]Department of Otolaryngology University of Melbourne Melbourne Australia

出　　处：《中华耳鼻咽喉头颈外科杂志》2006年第9期702-704,共3页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：国家留学基金(22841039)

摘　　要：目的在人工耳蜗植入的动物实验中,了解电极在小动物耳蜗内的位置以及电极物理构造的完整性。方法设计了一种适合对实验室小动物摄像的微焦 X 线影像系统,其关键技术包括一个小于10μm的微焦 X 线源的应用以及射线源-投照物间距离和投照物-影像间距离的恰当选择。应用该设备分别对已行人工耳蜗电极植入的猫、豚鼠和大鼠各5只进行了头颅微焦 X 线摄片观察。结果利用这种微焦摄像法,耳蜗影像的边缘部分对比度有明显提高;可以更好地确定电极组在耳蜗内的位置和深度;它能够发现25μm粗细的铂铱导线的结构完整与否。结论该方法是实验室小动物人工耳蜗植入研究的一种重要工具,对电诱发听性脑干反应不能引出的情况下的故障检查,也是一个有用的方法。Objective To develop an imaging system suitable for cochlear implant research on small laboratory animals. Methods A novel micro-focus X-ray imaging system was developed. The key features of the system were the use of a micro-focus X-ray source （less than 10 micrometers ） and an appropriate choice of source-object and object-image distance. The new X-ray modality was evaluated on heads of cats, guinea pigs and rats. Results It proved to be an useful tool to provide excellent image of small animal cochlea, allowing a clear electrode position to be established, and also helped greatly in detecting the breakage of electrode array. Conclusions Experimental studies performed in cats, guinea pigs and rats confirmed that micro-focus radiography was an important tool for cochlear implant research in laboratory animals.

关 键 词：耳蜗植入 电极 X线 

分 类 号：R764[医药卫生—耳鼻咽喉科]