麝香保心丸对颈动脉粥样硬化斑块的影响  

Effects of Shexiang Baoxin Pill on Carotid Atheromatous Plaque

作　　者：洪永敦[1] 吴辉[1] 赵萍[1] 莫鸿辉[1] 薛峥[2] 王向培[1] 黄汉超[1] 陈宏珪[1] 

机构地区：[1]广州中医药大学第一附属医院,广州510405 [2]广州市中医医院

出　　处：《中国中西医结合杂志》2006年第9期780-783,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：目的探讨麝香保心丸对颈动脉粥样硬化的治疗作用。方法41例颈动脉粥样硬化患者,随机分为治疗组与空白对照组。治疗组31例给予麝香保心丸加西医常规治疗;对照组10例予西医常规治疗。两组患者均连续用药6个月。观察两组颈动脉粥样硬化斑块、C-反应蛋白(CRP)、纤维蛋白原(FIB)、D-二聚体、血脂等变化情况。结果治疗组治疗后颈动脉平均斑块数、斑块总积分、斑块面积、CRP、FIB、D-二聚体较治疗前降低,差异有显著性(P<0·05或P<0·01),并且低于对照组治疗后(P<0·05)。治疗期间两组均无严重不良反应出现。结论麝香保心丸可作为治疗颈动脉粥样硬化的一种有效而安全的药物。Objective To study the effects of Shexiang Baoxin Pill （SBP） in treating carotid atherosclerosis （CAS）. Methods Forty-one CAS patients were randomly assigned to 2 groups, the SBP group （31 cases） treated with SBP plus routine treatment and the control group （10 cases） with routine treatment only. Both were treated for 6 months. The changes of carotid atheromatous plaque （CAP）, C reactive protein （CRP）, fibrinogen （FIB）, D-dimer and blood lipids, etc. were observed. Results After treatment, average number, total scores and area of plaque, as well as levels of CRP, FIB and D-dimer decreased significantly in the SBP group （P〈 0.05 or P 〈 0.01）, and were lower than those in the control group after treatment respectively （P〈0.05）. No severe adverse reaction occurred in both groups. Conclusion SBP is a safe and effective remedy for treatment of CAS.

关 键 词：麝香保心丸 颈动脉 粥样硬化斑块 

分 类 号：R259[医药卫生—中西医结合]