β-溶血性链球菌、结核分枝杆菌与银屑病相关性  

Relationship Between β-Streptococcus haemolyticus, Mycobacterium tuberculosis, and Psoriasis

作　　者：陈小红[1] 韩建德[2] 李斌[2] 吴勤学[1] 

机构地区：[1]中国医学科学院中国协和医科大学皮肤病研究所,江苏南京210042 [2]中山大学附属第一医院皮肤科,广东广州510080

出　　处：《中山大学学报（医学科学版）》2006年第5期541-544,548,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：教育部博士点基金资助项目(1998002329)

摘　　要：【目的】探讨各型银屑病患者血清中抗β-溶血性链球菌、结核分枝杆菌及其提取物的IgG,IgM和IgA抗体水平和可能的意义。【方法】用ELISA法测定点滴状(36例)、斑块状(36例)、红皮病型(30例)、关节型(15例)、脓疱型(30例)共银屑病患者147例及正常对照(36例)血清中抗β-溶血性链球菌、结核分枝杆菌整菌、培养液和胞浆提取物的IgG、IgM和IgA抗体。【结果】各型银屑病患者血清中可检出不同水平的抗两种微生物三类成份的抗体,整菌抗原免疫反应最强,点滴状银屑病抗体水平最高;点滴状和斑块状银屑病患者血清中抗两种微生物IgG、IgM抗体水平高于正常对照组,并且抗β-溶血性链球菌抗体与抗结核分枝杆菌抗体有相关性。【结论】银屑病患者血清中存在抗β-溶血性链球菌、结核分枝杆菌及其提取物抗体,两种微生物对银屑病的免疫反应有相似之处,提示β-溶血性链球菌、结核分枝杆菌与银屑病可能存在相关性。[Objectives] To study antibodies of IgG, IgM, and IgA classes against whole β-Streptococcus haemolyticus, Mycobacterium tuberculosis and their extracts in sera from the patients with various types of psoriasis and their significance. [Methods] Detecting antibodies of IgG, IgM, and IgA classes against whole β-Streptococcus haemolyticus, Mycobacterium tuberculosis, culture extract and cytoplasmic extract as antigens by using ELISA in sera from 147 patients with psoriasis-psoriasis guttata （36 cases）, psoriasis enplaques （36 cases）, psoriasis erythrodermia （30 cases）, psoriasis arthropathica （15 cases） and psoriasis pustulosa （30 cases） and 36 normal controls. [ Results ] The titre and class of antibodies against three antigens from the two kinds of bacteria were detected in various types of patients with psoriasis. Immunologic reaction against the whole bacteria antigen in both β-Streptococcus haemolyticus and Mycobacterium tuberculosis was the strongest, antibodies of IgG were the highest in patient with psoriasis guttata. Antibodies of IgG, IgM were significantly higher in patients with psoriasis guttata and psoriasis enplaques than those in normal controls against the two kinds of bacteria, and they were correlated between β-Streptococcus haemolyticus and Mycobacteritan tuberculosis. [Conclusion] There might be different antibodies of IgG, IgM, and IgA against β-Streptococcus haemolyticus, Mycobacterium tuberculosis and their extracts in various types of psoriasis. The immunologic reaction with both β-Streptococcus haemolyticus and Mycobacterium tuberculosis in sera from psoriasis was similar. There might be the relationship between β- Streptococcus haemolyticus, Mycobacterium tuberculosis and psoriasis.

关 键 词：银屑病 Β-溶血性链球菌 结核分枝杆菌 免疫球蛋白 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]