急性颅脑损伤胰岛素抵抗与细胞因子水平变化的关系及其意义  

Dynamic changes and clinical significance of serum insulin level and cytokines of patients with acute brain injury

作　　者：窦晓林[1] 袁平[1] 毛宗雯[1] 杨倩[1] 姚旗[1] 蒋梅英[1] 孙农[1] 

机构地区：[1]贵阳市第四人民医院ICU

出　　处：《创伤外科杂志》2006年第5期391-393,共3页Journal of Traumatic Surgery

摘　　要：目的探讨急性颅脑损伤患者是否存在胰岛素抵抗(IR)及与肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)的关系。方法测定106例急性颅脑损伤患者和30例对照组的空腹血糖(FBG)、空腹胰岛素(FINS)、TNF-α、IL-6的水平,并计算胰岛素敏感性指数(IAI),以评估颅脑损伤患者IR的严重程度,并分析各参数之间的相关性。结果中、重型颅脑损伤患者存在胰岛素抵抗及高细胞因子水平。IAI与TNF-α及IL-6的直线回归分析,直线关系r分别为-0.87和-0.85,差异有显著性(P<0.01)。结论重型颅脑损伤患者的IR程度与颅脑损伤的程度、TNF-α、IL-6的水平有显著相关性,其IR程度与TNF-α的升高有关。Objective To explore the relation of serum insulin level with cytokine contents in patients of acute brain injury. Methods Serum FBG,FINS,TNF-α and IL-6 were measured in acute brain injury（ 106 cases） and control group（30 cases）. The degree of insulin resistance（ IR）was assessed by calculating IAI and the relations between these indices were assayed. Results IR and hypercytokine contents occurred in the patient with severe brain injury,IAI was significantly correlated with TNF-α and IL-6. The ＂r＂ were -0.87 and -0.85 respectively, which were very significantly different（ P 〈 0.01 ）. Conclusion The degrec of IR was significantly correlated with degree of injury severity.

关 键 词：颅脑损伤 胰岛素 细胞因子 胰岛素抵抗 

分 类 号：R651.12[医药卫生—外科学]