血清抗肌内膜抗体IgA和IgG水平检测在谷胶病诊断中的意义  

Significance of Detection of Levels of Anti-Endomysial Antibody Immunoglobulin A,Immunoglobulin G in Diagnosis of Celiac Disease

作　　者：潘道香[1] 唐久来[1] 吴德[1] 许晓燕[1] 王德农[2] 

机构地区：[1]安徽医科大学第一附属医院儿科,合肥230022 [2]美国斯坦福大学医学院

出　　处：《实用儿科临床杂志》2006年第17期1168-1169,共2页Journal of Applied Clinical Pediatrics

基　　金：安徽省教委资助项目资助(2001J1118)

摘　　要：目的探讨我国是否存在谷胶病的“冰山”现象,研究人群血清中抗肌内膜抗体(AEA)IgA和IgG水平,为本病的功能基因学研究提供基础。方法对谷胶病高发人群136例和正常50例患者采用ELISA法,比较两组血清AEA IgA和IgG平均水平和阳性率。结果高发人群组AEA IgA和IgG水平(17.69±2.97,15.23±2.36)显著高于正常人群(11.65±2.75,12.25±1.86)(P<0.01)。高发组2例AEA IgA和IgG均呈强阳性。结论我国存在谷胶病的“冰山”现象,亦即存在为数不少未被明确诊断的谷胶病患者。值得临床重视和对易患人群进一步研究。Objective To investigate whether iceberg phenomenon of celiac disease（gluten - sensitive enterpathy,GSE） exisls among the people of China, and study on the levels of anti endomysial antibody （AEA） IgA and IgG, which provide the foundalion for studying functional genome of GSE. Methods One hundred and thirty- six cases liability crowd,which showed part symploms of GSE,were selected as case group and 50 cases of normal were selected as control group. Enzyme- linked immunosorbent assay was used to delect the level of 2 groups and positive rate of Alga was compared between 2 groups. Results The levels of AEA IgA and IgG in case group（ 17.69 ± 2.97, 15.23 ± 2.36）were significantly higher than those of control group（ 11. 65 ± 2.75, 12.25 ± 1. 86 ）, especially 2 strong positive cases were found in case group. Conclusion Iceberg phenomenon of celiac disease exists in the people of China, which means many celiac disease patients have not been diagnosed and it need us far more research.

关 键 词：谷胶病 谷蛋白 抗肌内膜抗体 IGA IGG 

分 类 号：R725.7[医药卫生—儿科]