安脑片治疗癫痫的药效观察  

Antiepilepsy effect of Annao Tablet

作　　者：方若鸣[1] 方更利[1] 方永奇[1] 

机构地区：[1]广州中医药大学,广东广州510405

出　　处：《中成药》2006年第9期1323-1325,共3页Chinese Traditional Patent Medicine

基　　金：广州中医药大学第二临床医学院基金项目(Eyky06A1)

摘　　要：目的:研究安脑片(石菖蒲)抗癫痫的作用。方法:灌胃给药,观察安脑片对抗苦味毒、硫代氨基脲、最大电休克、青霉素点燃癫痫。结果:安脑片有抗苦味毒和硫代氨基脲引起小鼠惊厥的作用,显著延长惊厥潜伏期,减少惊厥次数,延迟死亡时间;能对抗最大电休克发作,明显降低发作率;能降低癫痫的发作级别,延长发作潜伏期,减少WDS次数。结论:安脑片有显著抗癫痫作用。AIM ： To study the antiepileptic effect of Annao Tablet （ β-asarone extracted from Acorus tatarinowii schott）. METHODS： The medicine was administered orally. The effects were observed in mouse＇s convulsion models induced by picrotoxin, thiosemicarbazide, maximal electroshock seizure （MES） and Penicillin G. RESULTS： Annao Tablet had obvious effect against convulsion induced by picrotoxin and thiosemicarbazide, postponed the delitescence, reduced the convulsion times, prolonged the survival time; antagonized MES. The medicine could depress the epileptic degree, postpone spasm latent period, reduce the wet dog shack times. CONCLUSION： Annao Tablet has obvious antiepileptic effect.

关 键 词：石菖蒲 安脑片 Β-细辛醚 癫痫 小鼠 

分 类 号：R285.6[医药卫生—中药学]