医药中间体5-氨基-2,4,6-三碘异酞酸的合成研究  

Study on synthesis of 5-amino-2,4,6-triiodo-isophthalic acid as medicine intermediate

作　　者：黄伯芬[1] 王樱[2] 程斌[3] 

机构地区：[1]南昌大学材料科学与工程学院,南昌330047 [2]南昌工程学院,南昌330029 [3]江西省科学院应用化学研究所,南昌330029

出　　处：《化工新型材料》2006年第9期43-45,36,共4页New Chemical Materials

摘　　要：以5-硝基-异酞酸为原料,通过还原、碘取代反应,生成5-氨基-2,4,6-三碘异酞酸。重点对碘取代反应中反应介质、碘化剂的选取及碘化剂用量、反应温度、反应时间等参数及精制方法对反应得率影响进行了讨论,确定了最佳配方和工艺条件。5-amino-2,4,6-triiodo-isophthalic acid was synthesized from 5-nitro-isophthalic acid by reduction and iodinate substitution reactions. The factors affecting the iodinate substitution reaction yield, such as reaction medium, choice of iodinate agent, chlorinated iodine dose, reaction temperature, reaction time and refining method of 5-amino-2, 4,6-triiodo-isophthalic acid and etc. , were studied The optimum reactant compostion and reaction conditions were obtained.

关 键 词：医药中间体 5-氨基-2 4 6-三碘异酞酸 合成 

分 类 号：TQ463.2[化学工程—制药化工]