含La医用316L不锈钢的体外抗凝血性能研究  

STUDY OF IN VITRO ANTICOAGULANT PROPERTY OF THE La ADDED MEDICAL 316L STAINLESS STEEL

作　　者：杨化娟[1] 杨柯[1] 张炳春[1] 

机构地区：[1]中国科学院金属研究所

出　　处：《金属学报》2006年第9期959-964,共6页Acta Metallurgica Sinica

基　　金：国家高技术研究发展规划资助项目2001AA320604

摘　　要：系统研究了在医用316L不锈钢中加入0．05%La后的体外抗凝血性能．结果表明。与传统医用316L不锈钢相比,含La医用316L不锈钢较少地粘附和激活血小板,且动态凝血时间及血浆复钙时间均延长,表明其对内源性凝血因子的激活程度下降,抗凝血性能提高．通过测量材料的接触角,计算了表面张力及材料与血液之间的界面张力,从表面能的角度分析了材料的抗凝血机理．The in vitro anticoagulant property of a medical grade 316L stainless steel with 0.05% La addition was systematically studied. The results showed that, compared with the conventionally used medical 316L stainless steel, the La added 316L steel possesses less platelets adhesion and less activation of the platelets, and their kinetic clotting time and the plasma recalcification time become longer, which reveals that the activation extent of the latter on intrinsic coagulation factors is smaller than the former and the anticoagulant property of the latter is better. Through measurement of the contact angles of the steels, and calculations of the surface tension of the steels and the interfacial tension between the steels and the blood, the anticoagulant mechanism of the steels was analyzed from the viewpoint of surface energy.

关 键 词：医用316L不锈钢 LA 抗凝血 表面能 

分 类 号：R318.08[医药卫生—生物医学工程] TG142.71[医药卫生—基础医学]