猪丹毒QL251弱毒株安全性及免疫原性试验  

An Attenuated Erysipelothrix rhusiopathiae QL251

作　　者：罗玉峰[1] 钱心元[1] 房艳丽[1] 

机构地区：[1]中国兽药监察所

出　　处：《中国兽药杂志》1996年第4期18-20,共3页Chinese Journal of Veterinary Drug

摘　　要：猪丹毒ＱＬ２５１弱毒株是我所保存的猪丹毒强毒菌种Ｃ４３００９的变异株，对其进行了毒力和免疫原性的测定，该菌株毒力原来是３－５个活菌可致死小白鼠，现在对小白鼠皮下注射７．４×１０~８活菌，小白鼠全部健活，对敏感猪皮下注射９．４×１０^（１０）活菌均健活且无任何反应；小白鼠免疫９－１２个活菌７２％保护，对猪免疫２９０－５９０×１０~４活菌１００％保护。Abstract The attenuated Erysipelothrix rhusiopathiae strain QL251 is a mutant derived from the virulent strain C43009 preserved in the bacterium bank of the Control institute. Its virulence decreased significantly. Mice inoculated with a dose of 7.4 ×10￣8 bacteria survived healthily while its progenitor strain C43009 killed all the mice in a dose of 3-5 bacteria. Inoculating with 9.4 ×10￣(10) bacteria of QL251 subcutaneously induced no any adverse reaction in susceptible pigs. 72% mice vaccinated with a dose of 9-12 bacteria and 100% pigs vaccinated with 290-590 ×10￣4 bacteria were protected against challenge with virulent strajns C43006 and C43008.

关 键 词：猪丹毒 弱毒株 菌株 免疫原性 

分 类 号：S852.61[农业科学—基础兽医学] S858.285.1[农业科学—兽医学]