Auditory cortical responses evoked by pure tones in healthy and sensorineural hearing loss subjects： functional MRI and magnetoencephalography  

作　　者：ZHANG Yun-ting GENG Zuo-jun ZHANG Quan LI Wei ZHANG Jing 

机构地区：[1]Department of Radiology, General Hospital of Tianjin Medical University, Tianjin 300052, China [2]Department of Radiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China

出　　处：《Chinese Medical Journal》2006年第18期1548-1554,共7页中华医学杂志（英文版）

摘　　要：Background Blood oxygen level dependent functional magnetic resonance imaging （fMRI） and magnetoencephalography are new techniques of brain functional imaging which can provide the information of excitation of neurons by measure the changes of hemodynamics and electrophysiological data of local brain tissue. The purpose of this study was to study functional brain areas evoked by pure tones in healthy and sensorineural hearing loss subjects with these techniques and to compare the differences between the two groups. Methods Thirty healthy and 30 sensorineural hearing loss subjects were included in this study. In fMRI, block-design paradigm was used. During the active epoch the participants listened to 1000 Hz, sound pressure level 140 dB pure tones at duration 500 ms, interstimulus interval 1000 ms, which presented continuously via a magnetic resonance-compatible audio system. None stimulus was executed in control epoch. In magnetoencephalography study, every subject received stimuli of 1000 Hz tone bursts delivered to the bilateral ear at duration 8 ms, interstimulus intervals 1000 ms. Sound pressure level in healthy subjects was 30 dB; in sensorineural hearing loss subjects was 20 dB above everyone＇ s hearing threshold respectively. All subjects were examined with 306-channel whole-scalp neuromagnetometer. Results In fMRI, all subjects showed significant activations in bilateral Heschl＇s gyri, anterior pole of planum temporale, planum temporale, precentral gyri, postcentral gyri, supramarginal gyri, superior temporal gyri, inferior frontal gyri, occipital lobes and cerebellums. The healthy subjects had more intensive activation in bilateral Heschl＇s gyri, anterior pole of planum temporale, inferior frontal gyri, left superior temporal gyri and right planum temporale than the hearing loss subjects. But in precentral gyri, postcentral gyri and occipital lobes, the activation is more intensive in the hearing loss subjects. In magnetoencephalography study, both in the hearing loss and the healthy subjects,Background Blood oxygen level dependent functional magnetic resonance imaging （fMRI） and magnetoencephalography are new techniques of brain functional imaging which can provide the information of excitation of neurons by measure the changes of hemodynamics and electrophysiological data of local brain tissue. The purpose of this study was to study functional brain areas evoked by pure tones in healthy and sensorineural hearing loss subjects with these techniques and to compare the differences between the two groups. Methods Thirty healthy and 30 sensorineural hearing loss subjects were included in this study. In fMRI, block-design paradigm was used. During the active epoch the participants listened to 1000 Hz, sound pressure level 140 dB pure tones at duration 500 ms, interstimulus interval 1000 ms, which presented continuously via a magnetic resonance-compatible audio system. None stimulus was executed in control epoch. In magnetoencephalography study, every subject received stimuli of 1000 Hz tone bursts delivered to the bilateral ear at duration 8 ms, interstimulus intervals 1000 ms. Sound pressure level in healthy subjects was 30 dB; in sensorineural hearing loss subjects was 20 dB above everyone＇ s hearing threshold respectively. All subjects were examined with 306-channel whole-scalp neuromagnetometer. Results In fMRI, all subjects showed significant activations in bilateral Heschl＇s gyri, anterior pole of planum temporale, planum temporale, precentral gyri, postcentral gyri, supramarginal gyri, superior temporal gyri, inferior frontal gyri, occipital lobes and cerebellums. The healthy subjects had more intensive activation in bilateral Heschl＇s gyri, anterior pole of planum temporale, inferior frontal gyri, left superior temporal gyri and right planum temporale than the hearing loss subjects. But in precentral gyri, postcentral gyri and occipital lobes, the activation is more intensive in the hearing loss subjects. In magnetoencephalography study, both in the hearing loss and the healthy subjects,

关 键 词：functional magnetic resonance imaging MAGNETOENCEPHALOGRAPHY pure tones auditory cortex 

分 类 号：R764[医药卫生—耳鼻咽喉科]