Pay more attention to the immunologically comparative evaluation of HIV-1 DNA vaccine in combination with adjuvant cytokines： a long way to go  

作　　者：REN Xiao-feng 

机构地区：[1]Department of Preventive Veterinary Medicine College of Veterinary Medicine Northeast Agricultural University Harbin 150030, China

出　　处：《Chinese Medical Journal》2006年第18期1583-1584,共2页中华医学杂志（英文版）

摘　　要：To the Editor： A recent article entitled ＂HIV-1 DNA vaccine with adjuvant cytokines induces specific immune responses against HIV-1 infection in mice＂ was published in the Chinese Medical Journal. The authors descriptively analyzed the adjuvant potential of an interleukin-12 （IL-12）, interleukin-18 （IL-18）, regulated on activation of normal T-cell expressed and secreted factor （RANTES）, macrophage inflammatory protein 1 alpha （MIP-1α or stromal cell derived factor 1 （SDF-1） plasmid when coimmunized with an HIV Gag gene-based DNA vaccine. Consequently the authors believed that IL-12, IL-18, or SDF-1 plasmid DNA potentially serves as immune adjuvants in combination with therapeutic HIV-1 DNA vaccine. The RANTES, MIP-1α plasmid DNA potentially serves as Immune adjuvants in combination with HIV-1 prophylactic vaccine. Although the experiment allows us to consider such a coinoculation strategy as one of the means against HIV-1 infection, some special attentions should be highlighted.To the Editor： A recent article entitled ＂HIV-1 DNA vaccine with adjuvant cytokines induces specific immune responses against HIV-1 infection in mice＂ was published in the Chinese Medical Journal. The authors descriptively analyzed the adjuvant potential of an interleukin-12 （IL-12）, interleukin-18 （IL-18）, regulated on activation of normal T-cell expressed and secreted factor （RANTES）, macrophage inflammatory protein 1 alpha （MIP-1α or stromal cell derived factor 1 （SDF-1） plasmid when coimmunized with an HIV Gag gene-based DNA vaccine. Consequently the authors believed that IL-12, IL-18, or SDF-1 plasmid DNA potentially serves as immune adjuvants in combination with therapeutic HIV-1 DNA vaccine. The RANTES, MIP-1α plasmid DNA potentially serves as Immune adjuvants in combination with HIV-1 prophylactic vaccine. Although the experiment allows us to consider such a coinoculation strategy as one of the means against HIV-1 infection, some special attentions should be highlighted.

分 类 号：R512.91[医药卫生—内科学]