氢氯噻嗪对高血压患者血清高敏C-反应蛋白浓度的影响  

Effects of hydrochlorothiazide on serum levels of high sensitive C-reactive protein in hypertensive patients.

作　　者：周永[1] 牛建清[2] 吴寿岭[2] 王丰[3] 梁万年[1] 

机构地区：[1]首都医科大学公共卫生与家庭医学院,北京100069 [2]华北煤炭医学院附属开滦医院 [3]华北煤炭医学院流行病与卫生统计学教研室

出　　处：《中国综合临床》2006年第11期966-968,共3页Clinical Medicine of China

摘　　要：目的研究高血压患者服用氢氯噻嗪(HCTZ)后血清高敏C-反应蛋白(hsCRP)浓度的变化。方法732例高血压患者同时服用氢氯噻嗪12.5mg,1次/d。6周后,比较资料完整的715例患者治疗前后血清hsCRP浓度的变化。并按患者的降压疗效分组比较不同降压反应对hsCRP浓度的影响。结果715例患者治疗前后血清hsCRP浓度分别为2.39和2.10mg/L,治疗后血清hsCRP浓度低于治疗前(P<0.05)。治疗后血压达标组血清hsCRP浓度低于非达标组(P<0.05);治疗前后不同收缩压水平患者血清hsCRP浓度不同(P<0.05)。血清hsCRP水平与治疗前后收缩压水平均呈正相关(r=0.10,r=0.12,P<0.05)。多元线性回归结果表明体质指数、治疗后收缩压水平、年龄影响患者治疗后血清hsCRP浓度。结论高血压患者服用氢氯噻嗪后血清hsCRP浓度下降;收缩压水平是影响血清hsCRP水平的主要因素。Objective To study the effects of hydrochlorothiazide （HCTZ） on the serum levels of high sensitivity C-reactive protein （hsCRP）in hypertensive patients. Methods A total of 732 patients took 12.5 mg hydrochlorothiazide（1/day） for six weeks. Changes of the serum hsCRP levels in 715 patients with full records were compared before and after treatment with HCTZ. Results After 6 weeks treatment, the serum hsCRP levels deceased significantly compared with baseline （ 2.39 mg/L vs 2.10 mg/L, respectively,P 〈 0.05 ）. The serum hsCRP levels of the group with good response was lower than that of the groups with bad response. And the levels of SBP of baseline or post-treatment were both positively associated with the levels of serum hsCRP （r =0.10,r = 0.12,P 〈0. 05 rspectively）. In the muhifactor linear regression analyses, the body mass index, post-treatment SBP levels and the age showed independent correlations with serum hs-CRP levels. Conclusion The serum hsCRP levels decrease signifi- cantly in hypertensive patients after treatment with HCTZ and the levels of SBP are the main factors influencing the levels of serum hs-CRP.

关 键 词：高血压 氢氯噻嗪 C-反应蛋白 

分 类 号：R544.1[医药卫生—心血管疾病]