血浆纤维蛋白原在冠心病发病中的作用  

The Role of Plasmatic Fibrinogen in the Pathogenesis of Coronary Heart Disease

作　　者：马志祥[1] 刘安丽[1] 刘家恒[1] 张海燕[1] 陈鑫[1] 

机构地区：[1]河南省南阳医学高等专科学校,河南南阳473000

出　　处：《临床军医杂志》2006年第4期465-466,共2页Clinical Journal of Medical Officers

摘　　要：目的探讨血浆纤维蛋白原在冠心病发病中的作用。方法测定正常人82名、经冠状动脉造影诊断的冠心病(CHD)患者46例、急性心肌梗死(AM I)患者15例的血浆纤维蛋白含量。结果正常男女两性间无显著差别(P>0.05),随着年龄增长有增高趋势(P>0.05)。AM I组和CHD组的血浆纤维蛋白原明显高于正常对照组(P<0.01,P<0.05)。CHD患者的血浆纤维蛋白原含量与冠脉狭窄支数有密切关系。结论血浆纤维蛋白原在冠心病的发病中可能起重要作用。Objective To discuss the role of plasmatic fibrinogen in the pathogenesis of coronary heart disease （CHD）. Methods Fibrinogcnic levels in plasma were measured in 46 patients with CHD diagnosed by coronary radiography, 15 ones with acute myocardial infarction （AMI） and 82 healthy volunteers as control. Results In healthy volunteers, there was no significant difference in plasma fibrinogenic level between males and females （ P 〉 0. 05 ）. The plasma fibrinogcnic level of CHD or AMI group was significantly higher than that of the control group （ P 〈 0. 05, or P 〈 0. 01 ）. In the CHD group, the fibrinogcnic level in plasma was correlative to the number of the strictured coronary arteries. Conclusion It is suggested that fibrinogcn in plasma takes an importanl role in the the pathogcncsis of CHD.

关 键 词：冠心病 血浆纤维蛋白原 

分 类 号：R541.4[医药卫生—心血管疾病]