奈福泮与丁丙诺啡术后自控镇痛的效果比较  

Comparison of effects of patient-controlled intravenous analgesia with nefopam or buprenorphine after lower abdominal or lower limb surgery

作　　者：李秀泽[1] 孙德友[1] 

机构地区：[1]绵阳市中心医院麻醉科,四川绵阳621000

出　　处：《实用医药杂志》2006年第9期1039-1040,共2页Practical Journal of Medicine & Pharmacy

摘　　要：目的比较奈福泮和丁丙诺啡静脉自控镇痛(PCIA)对下腹部及下肢手术患者的镇痛效果。方法40例择期手术患者随机分为奈福泮组(N组)及丁丙诺啡组(B组),术后4、8、12、24、48h分别观察疼痛评分(VAS)、镇静评分(SS)及恶心、呕吐、呼吸抑制、皮肤瘙痒、尿潴留等不良反应。结果两组患者镇痛效果相似。N组镇静评分明显低于B组。术后24h B组恶心、呕吐等不良反应发生率明显高于N组。结论PCIA奈福泮对下腹部及下肢手术患者可以提供满意的镇痛效果,而且其不良反应发生率低。Objective To compare the clinical efficacy of nefopam or buprenorphine with a patient - controlled intravenous analgesia （PCIA） delivery system.Methods In the prospective,randomized,double blind study,authors evaluated 40 adult patients scheduled for elective lower abdominal or lower limb surgery undergoing general anesthesia. Immediatelly after operation,they were blindly randomized into two groups.Group nefopam （group N,n=20） was given 0.1% nefopam ＋5μg/ml fentanyl,group buprenorphine （group B,n=20） was given 0.0012% buprenorphine ＋5μg/ml fentanyl.The analgesic device was programmed 2ml/h,0.5ml on demand with a lockout time of 15 min.The total volume was 100ml.The patients were followed up for 48h and the visual analog scale （VAS）,the sedation score （SS）,the side effects such as nausea,vomiting,uroschsis,respiratory depression,pruritus,urlne retention were observed.Results VAS showed no difference between the two groups.The SS of group B was higher than that of group N （P〈0.05）.The rates of postoperative nausea and vomiting （PONV）of group B were higher than those of group N （P〈0.05）.Conclusion When used in postoperative PCIA, nefopam can provide the same and satisfied effects as buprenorphine with a lower frequency of PONV.

关 键 词：自控镇痛 奈福泮 丁丙诺啡 

分 类 号：R971.1[医药卫生—药品]