不同品系小鼠急性胰腺炎预后差异及其机制探讨  

The different prognosis of acute pancreatifis in different strain mice and its possible mechanisms

作　　者：吕金利 申海鹰[2] 沈利群 郭树军 周元国[2] 

机构地区：[1]153医院普通外科,河南郑州450042 [2]第三军医大学大坪医院外科研究所,重庆400042

出　　处：《实用医药杂志》2006年第9期1074-1076,共3页Practical Journal of Medicine & Pharmacy

基　　金：国家自然科学基金资助项目(No:30100106)

摘　　要：目的观察C57BL/6和BALB/C两品系小鼠急性胰腺炎预后差异,并探讨其预后差异的机制。方法腹腔内注射L-精氨酸的方法诱导两品系小鼠急性胰腺炎模型,观察其急性胰腺炎后24h病死率的差异,RT-PCR方法检测两品系小鼠肝、肺组织白细胞介素-1β(1L-1β)表达。结果急性胰腺炎时C57BL/6小鼠24h病死率(10%)与BALB/C小鼠病死率(40%)相比有显著性差异(P＜0．05)；两品系小鼠肝、肺组织1L-1β的表达在相同时相点有显著性差异(P＜0．05)。结论两品系小鼠急性胰腺炎时其组织炎症因子表达的差异与其病死率差异有明显相关性。Objective To observe the different prognosis of acute pancreatitis （AP） in C57BL/6 and BALB/c mice and investigate the possible mechanisms of the different prognosis. Methods The AP model was induced by injecting L-arginine （Arg） into the abdominal cavity of mice. The 24h death rate was observed in the two strains mice after establishment of AP model. The expression of intedeukin-1β in liver and lung tissue were detected by reverse transcription polymerase chain reaction （RT-PCR）. Results C57BL/6 AP mice had a lower death rate （10%） than BALB/c mice（40%）. The expression of interleukin-1β in liver and lung tissue had significant difference between two strains mice. Conclusion The significant difference in death rate may be related to the difference of tissue inflammatory factor in two strains mice.

关 键 词：急性胰腺炎 炎症因子 白细胞介素 

分 类 号：R657.51[医药卫生—外科学]