Coasting疗法对于高反应者IVF/ICSI周期结局的影响  

Effect of coasting on cycle outcome during in vitro fertilization/ intracytoplasmic sperm injection cycles in hyper-responders

作　　者：Kovács P. Mátyás S. Kaali S.G. 朱亮 

机构地区：[1]KaáliInstitute IVF Center, Istenhegyi ut 54/a, 1125 Budapest,Hungary Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第9期44-44,共1页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To investigate the effect of coasting on IVF outcome in GnRH agonist cycles.Design: Retrospective ana-lysis. Setting: Private IVF center.Patient(s): Infertile couples undergoing IVF/intracytoplasmic sperm injection (ICSI) treatment (normal responders [control], hyper- responders [coasting]- groups).Intervention(s): Coasting to reduce the risk of ovarian hyperstimulation syndrome (OHSS) among hyper- responders.Main Outcome Measure(s): Stimulation, embryology parameters, and pregnancy rate (PR).Result(s): The average length of coasting was 2.2 days.Age and baseline FSH were comparable to control cycles.There were more follicles and oocytes in the coasting group, but the number of fertilized oocytes and embryos transferred were similar.Implantation rate (22.4% vs.13.9% ) was higher in the control group but the PRs were comparable (45.1% vs.38.5% ).Within the coasting group, baseline, stimulation, and embryology parameters were comparable between successful and unsuccessful cycles.Pregnancy rates were comparable after 1, 2, and 3 or more days of coasting (36.3% vs.38.4% vs.40% ). Pregnancy rates were also comparable (28.5% vs.35.7% vs.44.4% ) when groups were compared based on change in E2 ( < 25% , 25% ～ 50% , > 50% ).Conclusion(s): Coasting for 3 days can be used successfully in the management of the hyper- responding patients during IVF.Objective： To investigate the effect of coasting on IVF outcome in GnRH agonist cycles. Design：Retrospective analysis. Setting： Private IVF center. Patient（s） ： Infertile couples undergoing IVF/intracytoplasmic sperm injection （ICSI） treatment （normal responders [control], hyper- responders [ coasting ] - groups）. Intervention （s） ： Coasting to reduce the risk of ovarian hyperstimulation syndrome （OHSS） among hyper-responders. Main Outcome Measure（s） ： Stimulation, embryology parameters, and pregnancy rate （PR）. Result（s） ：The average length of coasting was 2. 2 days. Age and baseline FSH were comparable to control cycles. There were more follicles and oocytes in the coasting group, but the number of fertilized oocytes and embryos transferred were similar. Implantation rate （22.4% vs. 13.9% ） was higher in the control group but the PRs were comparable （45. 1% vs. 38.5% ）. Within the coasting group, baseline, stimulation, and embryology parameters were comparable between successful and unsuccessful cycles. Pregnancy rates were comparable after 1, 2, and 3 or more days of coasting （36. 3% vs. 38.4% vs. 40% ） . Pregnancy rates were also comparable （28.5% vs. 35.7% vs. 44. 4% ） when groups were compared based on change in E2 （ 〈 25%, 25% - 50%, 〉 50% ） . Conclusion（s） ： Coasting for 3 days can be used successfully in the management of the hyper- responding patients during IVF.

关 键 词：高反应者 妊娠周期 IVF 疗法 ICSI 促性腺激素释放激素激动剂 卵母细胞单精子显微注射 卵巢过度刺激综合征 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]