对于持续宫腔内给予小剂量左炔诺孕酮联合口服雌二醇戊酸盐治疗的患者用数字评估乳腺摄片中的乳腺密度:一项初步研究  

Digitized assessment of mammographic breast densityin patients who received low-dose intrauterine levonorgestrel in continuous combination with oral estradiol valerate:A pilot study

作　　者：Lundstrm E. Sderqvist G. Svane G. 朱亮 

机构地区：[1]Department of Obstetrics and Gynecology,Karolinska University Hospital, SE-171 76 Stockholm,Sweden Dr

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第9期46-47,共2页Core Journal in Obstetrics/Gynecology

摘　　要：Objective: To perform a pilot study of the effects on the breast by low- dose intrauterine progestogen combined with estrogen.Design: A prospective pilot study.Setting: University hospital.Patient(s): Twenty postmenopausal women without any previous breast disorder.Intervention(s): Women were treated with a low- dose intrauterine system releasing 20 μ g/24 hours of levonorgestrel in continuous combination with 2 mg of oral E2 valerate.The effects on mammographic breast density, breast cell proliferation, and hormonal levels were followed for 18 months.Main Outcome Measure(s): Change in mammographic breast density and breast cell proliferation.Correlations with levels of hormones, growth factors, and binding proteins.Result(s): Three women showed an apparent increase in density.For the remaining 17 women the changes were only a few percent.Digitized assessment of density showed strong correlations with visual classification scales (rs = 0.96- 0.97). There was no increase in proliferation as expressed by the percentage of MIB- 1- positive breast cells in fine- needle aspiration biopsies.Increase in breast density displayed a positive correlation with patients age (rs = 0.52) and an inverse relationship with levels of E2 (rs = - 0.50) and free T (rs = - 0.50).Conclusion(s): Low- dose intrauterine administration progestogen may develop into an attractive alternative for hormonal therapy in postmenopausal women as endometrial protection may be achieved at very low systemic levels.Objective： To perform a pilot study of the effects on the breast by low - dose intrauterine progestogen combined with estrogen. Design： A prospective pilot study. Setting： University hospital. Patient（s） ：Twenty postmenopausal women without any previous breast disorder. Intervention（s）： Women were treated with a low- dose intrauterine system releasing 20 μg/24 hours of levonorgestrel in continuous combination with 2 mg of oral E2 valerate. The effects on mammographic breast density, breast cell proliferation, and hormonal levels were followed for 18 months. Main Outcome Measure（s）： Change in mammographic breast density and breast cell proliferation. Correlations with levels of hormones, growth factors, and binding proteins. Result（s）： Three women showed an apparent increase in density. For the remaining 17 women the changes were only a few percent. Digitized assessment of density showed strong correlations with visual classification scales （rs = 0.96- 0.97）. There was no increase in proliferation as expressed by the percentage of MIB- 1- positive breast cells in fine -needle aspiration biopsies. Increase in breast density displayed a positive correlation with patients age （rs = 0. 52） and an inverse relationship with levels of E2 （rs = -0.50） and free T （rs= -0.50） .Conclusion（s）：Low-dose intrauterine administration progestogen may develop into an attractive alternative for hormonal therapy in postmenopausal women as endometrial protection may be achieved at very low systemic levels.

关 键 词：左炔诺孕酮 雌激素治疗 乳腺密度 乳腺摄片 小剂量 宫腔内 雌二醇 初步 

分 类 号：R711[医药卫生—妇产科学]