窄波UVB联合局部外用钙泊三醇治疗白癜风  

Combination of narrow band UVB and topical calcipotriol for the treatment of vitiligo

作　　者：Goktas E.O. Aydin F. Senturk N. 冯义国 

机构地区：[1]Ondokuz Mayis University, School of Medicine, Department of Dermatology, TR- 55139 Kurupelit, Samsun, Turkey

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第9期4-4,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Narrow band ultraviolet B (NB-UVB) phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies. Objective: The aimof the present studywas to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo. Methods: NB-UVB treatment was given to 24 patientswith generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals. Result: The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 ± 19.6% and 39 ± 18.9% , respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm2 (range; 2930- 30980) and 18 (range; 12- 67) for the combination therapy, and 8867.5 mj/cm2 (range; 2500- 30980) and 24 (range; 15- 67) for the narrow band UVB therapy, respectively. Conclusions: These findings indicate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.Background： Narrow band ultraviolet B （NB-UVB） phototherapy has been used successfully for the treatment of vitiligo. Recently, topical calcipotriol has also been claimed to be effective, either as monotherapy or as a part of combination therapies. Objective： The aimof the present studywas to compare the clinical efficacy of NB-UVB and NB-UVB plus topical calcipotriol in the treatment of vitiligo. Methods： NB-UVB treatment was given to 24 patientswith generalized vitiligo three times weekly. Topical calcipotriol cream was only applied to the lesions located on the right side of the body. Treatment was continued for 6 months. Treatment efficacy was evaluated by determining the average response rates of the lesions at 3-month intervals. Result： The average response rates of patients receiving combination of NB-UVB plus calcipotriol and NB-UVB alone were 51 ± 19. 6% and 39 ± 18.9%, respectively. The median cumulative UVB dose and number of UVB exposures for initial repigmentation were 6345 mj/cm^2 （range; 2930-30980） and 18 （range; 12-67） for the combination therapy, and 8867.5 mj/cm^2 （range; 2500 - 30980） and 24 （range; 15 - 67） for the narrow band UVB therapy, respectively. Conclusions： These findings indi- cate that concurrent topical calcipotriol potentates the efficacy of NB-UVB in the treatment of vitiligo. This combination not only provides earlier pigmentation with lower total UVB dosage and less adverse UVB effects, but also reduces the duration and cost of treatment as well.

关 键 词：UVB照射 有效治疗 钙泊三醇 局部外用 白癜风 临床疗效 色素沉着 累积剂量 

分 类 号：R752.12[医药卫生—皮肤病学与性病学]