涂料厂内甲基异噻唑啉酮引发的接触性皮炎  

Contact dermatitis from methylisothiazol-inone in a paint factory

作　　者：Thyssen J.P Sederberg-Olsen N. Thomsen J.F Menné T. 张路坤 

机构地区：[1]Department of Dermato-venerology, Gentofte University Hospital, Niels Andersensve Dr.

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第9期42-43,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methylisothiazolinone (MI)- and not methyl chloro isothiazolinone (MCI) has recently been introduced in the European Union for use in products, such as paint, glue and cosmetics. The objective of this article is to describe a factory outbreak of contact allergy to MI and MCI preservatives. This factory outbreak describes allergic contact dermatitis towards MI in 4 patients of 14 persons working at a paint manufacturer. Patch test results from all patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization could be seen in the future. Our data show that MI holds a potential for eliciting and propably inducing contact allergy in humans. Whether this preservative is safe to use in cosmetics where billions of consumers are exposed needs a care full monitoring.Introduction of new potential contact-sensitizing chemicals have in the past led to epidemics of contact dermatitis. A new preservative containing only methylisothiazolinone （MI） - and not methyl chloro isothiazolinone （MCI） has recently been introduced in the European Union for use in products, such as paint, glue and cosmetics. The objective of this article is to describe a factory outbreak of contact allergy to MI and MCI preservatives. This factory outbreak describes allergic contact dermatitis towards MI in 4 patients of 14 persons working at a paint manufacturer. Patch test results from all patients showed positive reactions for MI and MCI/MI. The reactions were stronger for MI than MCI/MI indicating a primary sensitization to MI. The combination of MCI/MI remains widely used, and therefore various patterns of exposure and sensitization could be seen in the future. Our data show that MI holds a potential for eliciting and propably inducing contact allergy in humans. Whether this preservative is safe to use in cosmetics where billions of consumers are exposed needs a care full monitoring.

关 键 词：变态反应性接触性皮炎 甲基异噻唑啉酮 涂料 MCI 防腐剂 阳性反应 斑贴试验 致敏现象 

分 类 号：R758.22[医药卫生—皮肤病学与性病学]