脑室灌注肾上腺髓质素对大鼠血糖和血糖调节激素的影响  

EFFECT OF INTRACEREBRAL VENTRICULAR ADMINISTRATION OF ADRENOMEDULLIN ON BLOOD GLUCOSE AND ITS REGULATORY HORMONES IN RATS

作　　者：齐红伟[1] 赵咏梅[1] 郭育红 姬志娟[1] 盛树力[1] 刘月琴 

机构地区：[1]北京宣武医院多肽研究室,100053 [2]北京国防科工委福赛公司

出　　处：《中华内分泌代谢杂志》1996年第3期160-161,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：灌注脑室以不同溶剂配制的肾上腺髓质素(AM),观察并比较它们对血糖及血糖调节激素的影响.结果表明:(1)中枢给以生理盐水配制的AM,可使血浆胰岛素、C 肽明显升高,胰升糖素、血糖浓度降低.(2)用30%葡萄糖配制AM与单纯灌注糖溶液相比,AM可使血浆胰岛素、C肽明显升高,胰升糖素明显降低,血糖浓度则无差异.说明AM参与中枢神经系统对胰岛分泌激素的调节.After intracerebral ventricular administration of adrenomedullin (AM) in normal saline (NS) or 30% glucose to rats, the effects on blood glucose and glucose regulatory hormones were studied and compared. 1) Am in NS increased significantly the concentration of plasma insulin and C peptide, and decreased the concentration of glucagon and blood glucose. 2) As compared with 30% glucose alone, AM in 30% glucose raised significantly the plasma insulin and C peptide and decreased significantly the glucagon concentration, but the blood glucose level remained unchanged. The results showed that the AM plays a role in the regulation of pancreatic hormone secretion by central nerve system.

关 键 词：肾上腺髓质 血糖 胰岛素 脑室灌注 

分 类 号：Q578[生物学—生物化学]