糖尿病大鼠肺表面活性物质蛋白质基因表达的变化  

EXPRESSION OF PULMONARY SURFACTANT PROTEINS IN LUNG OF STREPTOZO-TOCIN DIABETIC RAT

作　　者：王晓川[1] 金勤立[1] 沈惟堂[1] 徐永华[2] 

机构地区：[1]上海医科大学儿科医院 [2]中国科学院上海分院细胞所

出　　处：《中华内分泌代谢杂志》1996年第3期162-164,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：利用分子杂交技术检测链脲佐菌素所致糖尿病大鼠肺表面活性物质蛋白质(SP)基因表达的变化.观察到糖尿病大鼠肺SP的基因表达均明显增加.SP-A mRNA的量培加十分明显,与对照组相比增加约2倍;SP-B mRNA与SP-C mRNA的变化比较接近,分别比对照组增加1倍.在胰岛素控制良好组,尿糖维持在微量(±)情况下,大鼠SP的基因表达与正常对照组无明显差别,提示部分严重糖尿病患者使用胰岛素治疗的恢复期发生呼吸窘迫综合征(RDS)可能与SP基因表达减少有关.Expression of pulmonary surfactant proteins(SP) was studied in lung of strep-tozotocin-diabetic rat. The levels of three kinds of SP(A,B,C) mRNA were all increased in diabetic rat lung. The level of SP-A mRNA in diabetic rats was increased about two times more than that of the control group. The change of SP-B mRNA was similar to that of SP-C in diabetic rats, and they were increased about one time more than that of their respective control group. There were no changes in three kinds of SP mRNA in diabetic rats, well treated with insulin, as compared with those of the control groups. These results probably can offer an useful explanation to some clinical problems in diabetes.

关 键 词：糖尿病 肺表面活性物质 蛋白质 基因表达 

分 类 号：R587.102[医药卫生—内分泌]