大鼠脑发育临界期内甲亢和甲减对中枢胆碱能神经元发育的影响  

EFFECT OF HYPERTHYROIDISM ON DEVELOPMENT OF ENCEPHALIC CHOLINER GIC NEURONS DURING THE CRITICAL STAGE OF BRAIN DEVELOPMENT IN RATS

作　　者：李昭瑛[1] 杨瑞芬 陈祖培[3] 马泰[3] 

机构地区：[1]山西医学院第一附属医院 [2]山西晋机医院 [3]天津医科大学

出　　处：《中华内分泌代谢杂志》1996年第3期165-167,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：对20日龄的甲亢及甲减大鼠的海马、大脑皮层、前脑基底和小脑中乙酰胆碱转移酶(CHAT)、乙酰胆碱酯梅(ACHE)各亚类的活性进行了测定.结果显示,胆碱能神经元是甲状腺激素的靶神经元.在脑发育临界期,甲亢和甲减均会造成各脑区胆碱能神经元突触发育障碍.甲状腺激素缺乏可使胆碱能神经元的发育和成熟明显落后,而甲状腺激素水平增高对胆碱能神经元成熟的影响在各脑区有差异:在大脑皮层增高,海马降低,前脑基底和小脑无明显变化.由于CHAT和ACHE对甲状腺激素水工的改变在不同脑区反应的差异可能造成乙酰胆碱的代谢紊乱.The choline acetyltransferase (CHAT) and the molecular forms of acetyl-cholinesterase (ACHE) activites in various brain regions of 20-day-old hypothyroid and hyper-thyroid rats were measured. The results provided the following information: 1) CHAT and ACHE activities were directly interrelated with thyroid hormones. 2) In both hypothyroid and hyperthyroid rats the nonextractable ACHE activity was distinctly decreased in every brain region, suggesting that both conditions were affected in the critical period of cholinergic synaptic development. 3) The ratio of membrane-bound ACHE to soluble ACHE decreased;it showed that thyroid hormone deficiency might distrub development and maturation of cholinergic neurons. 4) In most regions of the central nervous system,the CHAT seemed to be more affected than ACHE by thyroid hormones.

关 键 词：甲状腺功能减退 甲状腺功能亢进 乙酰胆碱酶 

分 类 号：R581.02[医药卫生—内分泌]