反映骨吸收的特异指标——尿胶原吡啶交联N末端肽  

A STUDY ON A SPECIFIC BONE RESORPTION MARKER:URINARY CROSS-LINKED COLLAGEN PEPTIDE

作　　者：薛延[1] 贾维维[1] 张海文[1] 董洁英[2] 于志坚[1] 

机构地区：[1]北京积水潭医院生化研究室,100035 [2]北京积水潭医院干部科,100035

出　　处：《中华内分泌代谢杂志》1996年第2期97-99,共3页Chinese Journal of Endocrinology and Metabolism

摘　　要：采用酶联免疫法（ELISA）测定了北京地区506名5～86岁健康人和230例原发性骨质疏松症（POP）及其他疾病患者尿中Ⅰ型胶原交联N末端肽（NTX）的水平。结果表明:（1）儿童时期尿中NTX为成人的十几倍,且男性明显高于女性（P<0.01）;（2）绝经后妇女尿中NTX水平为绝经前妇女和成年男性的1.4～2.2倍。（3）尿中NTX/Cr比值与尿中HOP/Cr、Ca/Cr比值呈明显正相关（P<0.01）,与腰椎骨密度呈明显负相关（P<0.01）The levels of urinary type Ⅰ collagen cross-linked N-telopeptides (NTX) were determined by ELISA in 506 Beijing normal subjects aged 5-86 years old and 230 patients with primary osteoporosis and other diseases. The results indicated: the levels of urinary NTX were more than ten times higher in children than in adults and significantly higher in boys than in girls (P<0. 01). In comparing males and premenopausal females with postmenopausal females, a mean 1. 4-2. 2 fold increase has been found in the later group. Urine NTX/Cr had a positive linear correlation with urinary HOP/Cr ratio and Ca/Cr ratio (P<0.01)and a negative linear correlation with lumbar spine bone mineral densi-ty(P<0. 01).

关 键 词：胶原交联 N末端肽 骨吸收 ELISA 

分 类 号：R68[医药卫生—骨科学]