自发性高血压大鼠的血压昼夜模式与血压波动性  

Circadian profiles of blood pressure and blood pressure variability in spontaneous hypertensive rats

作　　者：张黎明[1] 程勇[1] 王涤松[1] 苏定冯[1] 

机构地区：[1]第二军医大学药理学教研室

出　　处：《临床心血管病杂志》1996年第4期239-241,共3页Journal of Clinical Cardiology

基　　金：国家自然科学基金

摘　　要：采用计算机化清醒自由活动大鼠血流动力学监测技术，观测６０周龄自发性高血压大鼠（ＳＨＲ）的２４ｈ动态血压，研究其血压波动性（ＢＰＶ）与血压昼夜节律的关系。经计算机实时和脱机分析后可得到ＳＨＲ的２４ｈ、白昼、夜间等不同时间段的收缩压（ＳＢＰ）、舒张压（ＤＢＰ）及其波动性（ＳＢＰＶ、ＤＢＰＶ）等参数。大鼠的生理节律与人相反，夜间活动增多，血压上升，故将白昼ＳＢＰ比夜间ＳＢＰ下降≥１．３３ｋＰａ（１０ｍｍＨｇ）者定义为构型（ｄｉｐｐｅｒｓ）血压，反之为非构型（ｎｏｎ－ｄｉｐｐｅｒｓ）血压，本实验中非杓型血压ＳＨＲ占４６％。比较杓型与非杓型血压ＳＨＲ的血压值及ＢＰＶ，结果表明非杓型血压ＳＨＲ白昼ＳＢＰ明显高于杓型血压ＳＨＲ；非杓型血压ｓＨＲ白昼长期ＳＢＰＶ、ＤＢＰＶ及夜间短期ＳＢＰＶ明显高于杓型血压ＳＨＲ。非杓型血压ＳＨＲ的ＢＰＶ较高可能是其靶器官损伤严重的原因之一。The relationship between blood pressure variability (BPV) and circadian profiles of blood pressure(BP)was studied in spontaneous hypertensive rats(SHR)at 60 weeks of age. Intra-arterial BP was continuously recorded for 24 h in free action rats by a micro-computer system. On-line and off-line computer analysis of the BP curve allowed calculation of systolic(SBP) ,diastolic (DBP) BP and their variabilities (SBPV, DBPV) during 24 h, day-time and night-time.The rats could be divided into two groups :'dippers' and 'non-dippers',with and without a decrease of SBP bv 1.33 kPa from night to day, and a 46% prevalence of 'non-dippers' was found.The results showed :①day-time SBP of the 'non-dippers' was higher than 'dippers';②long-term SBPV and DBPV during day-time and short-term SBPV during night-time were higher in 'non-dippers' than 'dippers'.

关 键 词：高血压 血压变化 昼夜节律 血压波动性 

分 类 号：R544.102[医药卫生—心血管疾病]