伤口控释庆大霉素植入剂的临床应用  

TheClinicalUseofImplantationofGentamycinImplantsinSurgicalWounds

作　　者：李宝昌[1] 张福林[1] 赵晓山[1] 王志强[1] 金立国[1] 陈先[1] 张文芳[1] 

机构地区：[1]唐山市骨科医院

出　　处：《中华骨科杂志》1996年第9期572-573,共2页Chinese Journal of Orthopaedics

摘　　要：为了预防开放损伤感染，更有效地治疗骨髓炎和软组织感染，我们自１９８８年开始研制了伤口控释庆大霉素植入剂。１９９１年以来临床用于开放损伤患者１１５例，骨髓炎和软组织感染患者５８例，取得了较好的效果。１１５例开放伤的感染率为７．８３％，明显低于对照组的１９．４４％（Ｐ值＜０．０５）。伤口控释庆大霉素植入剂与庆大霉素骨水泥链珠比较具有体积小、含药量大、可随意放置和完全吸收等优点。Theauthorsstartedthestudyandmanufactureofcontrolablegentamycinreleasingim-plantsusinggelatinforthepreventionofinfectionofopenwoundsandthetreatmentofosteomyelitisandsofttissueinfections.Since1991,115casesoftraumaticinjuriesand58casesofosteomyelitisandsofttissueinfectionsweretreatedwiththismethod.Therateofinfectionofthe115caseswithopenwoundswas7.83%,whichwassignificantlylowerthanthat19.44%outofthe108controlcaseswith-outusingthegentamycinimplants.(19.44%,P<0.05).Comparedwiththegentamycin-PMMAbeads,thiscontrolablereleasinggentamycinimplantshavetheadvantagesofsmalervolume,largercontentofthemedicineandcanbeimplantedeasilyandabsorbedcompletely.

关 键 词：庆大霉素 植入剂 开放损伤 骨髓炎 

分 类 号：R551.305[医药卫生—血液循环系统疾病]