高压氧治疗脂肪栓塞综合征的实验研究  

TreatmentofFatEmbolismSyndromewithHyperbaricOxygenation:anExperimentalStudy

作　　者：王泰增[1] 吕刚[1] 金耀清[1] 

机构地区：[1]中国医科大学第一临床学院骨科

出　　处：《中华骨科杂志》1996年第8期508-509,共2页Chinese Journal of Orthopaedics

摘　　要：脂肪栓塞综合征（ＦＥＳ）主要表现为呼吸功能不全、ＰａＯ２下降、低氧血症而出现一系列病理改变。本实验应用高压氧（ＨＢＯ）对用骨髓制作的ＦＥＳ动物模型进行治疗。结果显示，ＨＢＯ能使ＰａＯ２明显升高；同时，由于ＰａＯ２升高，肺内渗出、水肿、出血等病变明显好转，机体状态获得改善。作者认为，提高ＰａＯ２在ＦＥＳ治疗中是关键，而ＨＢＯ是提高ＰａＯ２有效的方法之一，这为临床上应用ＨＢＯ治疗ＦＥＳ提供了实验依据。Fatembolismsyndrome(FES)ismainlymanifestedbyaseriesofpathologicalchangesresultedfromrespiratoryinsuficiency,decreaseofPaO2andhypoxemia.Thepurposeofthepresentstudywastodeterminetheefficacyofhyperbaricoxygenation(HBO)forthetreatmentofexperimentalFES.TheanimalmodelsofFESwereproducedbyinjectingbonemarrowintotheauricularveinsof12rabbits.19,43and67hoursaftertheinjection,6animalsweretreatedwithHBOand6animalswereusedascontrols.FESmodelswereconfirmedbySudanⅢstainofthepulmonary,andlivertissue.PaO2determinationsweredonebeforebonemarrowinjection,priortoHBOtreatmentandalsobeforesacrificeoftheanimalsbyprocuringbloodsamplesfromthefemoralarteriesortheabdominalaorta.TheresultsshowedthatHBOsignificantlyenhancedPaO2,whichplayedthechiefroleinthetreatmentofFESandthatHBOisoneofthemostefectivemethodstoincreasePaO2.ThestudyprovidedatheoreticalbasisforthetreatmentofFESbymeansofHBO.

关 键 词：脂肪栓塞综合征 高压氧 氧疗法 

分 类 号：R589.205[医药卫生—内分泌]