早期尿激酶静脉溶栓治疗急性脑梗死的疗效观察  

Observation on effective outcome of the thromboloysis therapy of early urorinase for acute cerebral infarction.

作　　者：何允兰[1] 

机构地区：[1]菏泽市立医院,山东菏泽274031

出　　处：《齐鲁护理杂志》2006年第09A期1645-1646,共2页Journal of Qilu Nursing

摘　　要：目的：探讨尿激酶静脉溶栓治疗急性脑梗塞的疗效。方法：将236例患者随机分为治疗组116例和对照组120例，在常规治疗基础上，治疗组分别给予尿激酶150万U、100万U、75万U，加入生理盐水100ml于35min内滴完，对照组分别给予降纤酶10U、5U、5U，加入生理盐水100ml静脉滴注，连用3d，治疗前后分别进行疗效评定，测血流变及相关指标。结果：在血流变学指标改善方面，尿激酶组明显优于降纤酶组。发病3个月时，3h内尿激酶治疗组临床治愈率62．07％，总有效率89．66％；12h内尿激酶治疗纽临床治愈率27．09％，总有效率82．76％，而降纤酶组治愈率仅6．67％，总有效率50％～70％，两组相比差异非常显著（P〈0．01）。结论：尿激酶静脉溶栓治疗急性脑梗塞安全有效，可减少出血等不良反应。Objectiue： To explore the thromboloysis therapy of urokinase for acutc cerebral infarction. Methods： 226 cases were randomized into the treatment group （n = 116） and the control group （n = 120）. On the basis of routione therapy, the treatment group were randomized to receine wrohinase 150 miuion unist, 100 miuion units and 75 miuion units in 35 minutes. The control group neceine defibrase 10u, 5u and 5u for 3 days. The clinical therapeutil, hemorrheology and other indexes wene analyzed before and during the treatment. Results： The hemorrheology indexes wene sinificant impraed in patients treated with urohinase as compared with the patients in plasinin. Mter 3 months, the cured rate was 62.07% and 27.09%, total efficiency rate were 89.66% and 82.76% in the patients treated with wrohinase in 3 hours and 3～12 hours. The cuned rate was 60.67%, the total efficiency rate was 50%～70% in the patients treated with defihrase The differenas wene significant （P 〈0.01）. Conclusion： The thromboloysis therapy of urohinase for acute cerebral infarction is effectine and safe without increasing adverse erents such as bleediy.

关 键 词：尿激酶 静脉溶栓 急性脑梗塞 

分 类 号：R473.5[医药卫生—护理学]