蛋白粒子的全新传染机制  

New infection mechanism of prion

作　　者：管涛[1] 高洪[1] 彭洁[1] 王修庚[1] 

机构地区：[1]云南农业大学动物科技学院,云南昆明650201

出　　处：《畜牧兽医杂志》2006年第5期36-38,41,共4页Journal of Animal Science and Veterinary Medicine

摘　　要：蛋白粒子主要引起人和动物的中枢神经系统退行性疾病,称之为蛋白粒子病。许多研究表明蛋白粒子病的致病因子缺乏棱酸,而是由特异的传染性蛋白质组成。该蛋白粒子是一种膜糖蛋白,至少有两种基本形式,即PrP^c和PrP^(ac)。PrP^(ac)是发病的直接原因,而PrP^c向PrP^(ac)转变则是发病的必要条件。文章就蛋白粒子概念、分子生物学以及全新的传染机制作了综合论述。Prion mainly causes the diseases of central nervous system in human and animal. Much evidence supports the hypothsis that the infectious agents of prion diseases are devoid of nucleid acid and instead are composed of a specific infections proteion. The prion protein is a membranous glycoproteit which has at least tow radical forms, PrP^c and PrP^sc. PrP^sc is the direct reason of leading to the diseases pathogenicity of prion lies in normal P,p^c transforning in to abnornal P,P^sc This revivew was involved with the conception, molecular biology,new infection mechanism of prion.

关 键 词：蛋白粒子 传染机制 PrP^c PrP^sc 

分 类 号：S852.659.7[农业科学—基础兽医学]