盐酸安非他酮缓释片的含量测定及释放度研究  

Content and Release Determination of Amfebutamone Hydrochloride Sustained Release Tablets

作　　者：王静[1] 林志立[2] 

机构地区：[1]江苏省药物研究所,南京210009 [2]福建省莆田学院,莆田351100

出　　处：《江苏药学与临床研究》2006年第4期218-220,共3页Jiangsu Pharmacertical and Clinical Research

摘　　要：目的建立盐酸安非他酮缓释片的含量测定方法并测定其释放度。方法采用紫外．可见分光光度法测定盐酸安非他酮缓释片的含量及释放度，测定波长为251nm。结果线性范围在4．895—16．316μg·ml^-1，r=0．9999；盐酸安非他酮缓释片的平均回收率为99．4％，RSD为0．69％。结论本法简便、准确、结果满意。AIM To develop a method for the assay and releasing of amfebutamone hydrochloride extended release tablets. METHODS UV-speetrophotometric method was performed at 251 nm. RESULTS The linear relationship equation is C （μg· ml^- 1 ） = - 3.82 × 10^ - 3 ＋ 4.31 × 10^ - 2 A with the ranger of 4.895 - 16.316μg· ml^- 1, r = 0.9998. The average recovery is 99.4 %, RSD = 0.69 （ n = 9）. CONCLUSION The method is convenient, accurate and the results of experiment satisfactory.

关 键 词：盐酸安非他酮 紫外-可见分光光度法 含量测定 释放度 

分 类 号：R927.2[医药卫生—药学]