2型糖尿病患者尿VEGF排泄的变化及其临床意义  

The changes of urinary vascular endothelial growth factor excretion and its clinical significance in type 2 diabetes mellitus

作　　者：范爱红[1] 叶山东[1] 常虹[1] 荆春艳[1] 陈燕[1] 徐卓华[1] 

机构地区：[1]安徽省立医院内分泌室,安徽230001

出　　处：《中国实验诊断学》2006年第8期915-917,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探讨2型糖尿病(T2DM)患者尿VEGF排泄的变化及临床意义。方法健康对照组30例;2型糖尿病患者70例,据其24小时尿白蛋白排泄率(UAER)分3组:(1)正常白蛋白尿组,UAER<20μg/min,29例;(2)微量蛋白尿组,UAER在20-200μg/min,20例;(3)大量蛋白尿组,UAER〉200μg/min,21例。结果与健康对照组相比,T2DM组尿VEGF排泄有明显升高,差异有统计学意义(P<0.01),正常蛋白尿组尿VEGF排泄已明显升高(P<0.05);T2DM组内,与正常蛋白尿组比较,微量蛋白尿组尿VEGF排泄率明显升高(P<0.05);大量蛋白尿组尿VEGF排泄率进一步升高(P<0.001)。相关分析显示:糖尿病患者尿VEGF与尿白蛋白(r=0.366,P<0.01)和尿视黄醇结合蛋白排泄率(r=0.325,P<0.01)呈正相关。结论糖尿病患者尿VEGF排泄增加并与肾脏病变的程度有关,尿VEGF排泄增加可能间接反映糖尿病肾组织VEGF表达和合成增加。Objective To study The changes of urinary vascular endothelial growth factor （VEGF） excretion and its clinical signifieanee in type 2 diabetes mellitas.Methods 30 normal controls and 70 type 2 diabetics were recruited into this study.70 type 2 diabetics were divided into 3 groups according to urinary albumin excretion rate （UAER） （1） normoalbuminuria group,UAER 〈 20 μg/min, n=29 ;（2） microalbuminuria group, UAER 20-200 μg/min, n = 20; （3）macroalbuminuria group, UAER ）200μg/ min, n = 21. Results （ 1 ） UVEGF excretion rate in T2DM was significantly higher than that in controls（ P 〈 0.01 ） ; UVEGF excretion rate in normal albuminuria group of type 2 diabetics was obviously higher than that in controls（ P 〈 0.05） ; （ 2 ） UVEGF excretion rate in microalbuminuria group was obviously higher than that in normoalbuminuria group （ P 〈 0.05） ; UVEGF excretion in macroal- buminuria group increased further （ P 〈0.001）;（3） The UVEGF excretion rate was positively related to UAER（r =0.366, P 〈0. 01 ）and urinary retinal binding - protein excretion （ r = 0.325, P 〈 0.01 ）. Conclusion Urinary VEGF excretion increased in type 2 diabetics, which is related to the degree of diabetic nephropathy; Inereased urinary VEGF excretion may reflect the increased expression and synthesis of renal tissue of diabetics.

关 键 词：糖尿病肾病 血管内皮生长因子 尿白蛋白排泄率 

分 类 号：R587.1[医药卫生—内分泌]