海洛因依赖与多巴胺D_2受体基因TaqⅠ A多态性的关联研究  

Correlated Study of Heroin Dependence and DRD_2 Receptor Gene TaqⅠ A Polymorphism

作　　者：徐振波[1] 徐丹[2] 张杰[2] 林勇[2] 陈晓刚[1] 陈林[1] 

机构地区：[1]广东省深圳市公安局刑事科学技术研究所,深圳518001 [2]昆明医学院神经科学研究所,昆明650031

出　　处：《昆明医学院学报》2006年第4期41-44,共4页Journal of Kunming Medical College

摘　　要：目的探讨海洛因依赖和多巴胺D2受体基因的关系.方法应用聚合酶链反应技术检测209例海洛因依赖者和109名正常对照多巴胺D2受体基因TaqⅠA多态性.结果海洛因依赖者和对照组之间的上述的基因型和等位基因频率的差异无显著性(P>0.05).结论多巴胺D2受体基因TaqⅠA多态性与海洛因依赖无关联.Objective To detect the relation between heroin dependence and DRD2 receptor gene Taq I A polymorphism. Methods Genotype and allele frequencies of DRD2 receptor gene Taq I A was examined in 209 heroin- dependence subjects and 109 normal controls. Results No difference in genotype and allele frequencies of polymorphism of DRD2 receptor gene Taq I A were observed between heroin - dependent subjects and normal controls （ x^2 = 3.69, P = 0. 16 and. x^2 = 3.10, P = 0. 08 ） . Conclusion The results suggested that polymorphism of DRD2 receptor gene Taq I A was not associated with heroin dependence.

关 键 词：海洛因依赖 多巴胺D2受体基因 多态性 

分 类 号：Q754[生物学—分子生物学]