桂芪生脉饮对免疫抑制大鼠呼吸道及全身免疫功能的影响  

Effects of Guqishengmaiyin on the Respiratory Tract and Systemic Immune Functions of Immune-suppressed Rats

作　　者：许琰[1] 熊磊[2] 张愉[1] 赵毅涛[2] 施明[1] 戴书颖[1] 

机构地区：[1]昆明医学院医学微生物学与免疫学教研室,昆明650031 [2]云南中医学院中医儿科学教研室,昆明650200

出　　处：《昆明医学院学报》2006年第4期50-54,共5页Journal of Kunming Medical College

基　　金：云南省教育厅科学研究基金项目(04Y296C)

摘　　要：目的探讨桂芪生脉饮对免疫抑制大鼠呼吸道及全身免疫功能的影响．方法将雄性SD大鼠（250～280g）随机分成5组（n=6只），正常对照组、免疫抑制组与高、中、低剂量治疗组；免疫抑制组肌注氢化可的松，药物治疗组给予氢化可的松和不同剂量的桂芪生脉饮灌胃14d后，检测大鼠呼吸道及全身免疫功能相关指标．结果桂芪生脉饮能明显提高免疫抑制大鼠血清凝集素水平（P〈0．01），增强免疫抑制大鼠腹腔巨噬细胞（PMφ）和肺泡巨噬细胞（AM）吞噬率（P〈0．05），增加免疫抑制大鼠外周血T淋巴细胞百分率（P〈0．05）和支气管肺泡灌洗液（BALF）中T淋巴细胞百分率（P〈0．05）；对大鼠脏器指数等指标无明显影响．结论桂芪生脉饮能增强免疫抑制大鼠呼吸道局部及全身免疫功能．Objective To explore the effect of Guqishengmaiyin on the respiratory tract and systemic immune functions of immune - suppressed rats. Methods Immune - suppressed model rats induced by hydrocortisone were filled stomachs with Guiqishengmaiyin one time a day. After 14 days and the immune modulation indicators in rats were detected. Some targets were detected on the respiratory tract and systemic immune functions of rats. Results Guqishengmaiyin can obviously increase the content of agglutinin in blood serum of rat （ P 〈 0.01 ）, phagocytosis of peritoneal macrophages （PMφ） （ P 〈0. 05） and alveola/macrophages （AM） （ P 〈 0. 05 ）, enhance the bronchus alveolus lavage fluid （BALF） and the peripheral blood T lymphocyte ratio （ P 〈 0. 05） . Conclusion Guqishengmaiyin can increase the cellular immunity functions of specific and nonspecific rats and had some effects on the respiratory tract immune functions.

关 键 词：桂芪生脉饮 免疫抑制 免疫功能 氢化可的松 大鼠 

分 类 号：R285.5[医药卫生—中药学]