四氧化二氮致大鼠急性肺水肿模型的探讨  

Studies on the rat model of acute pulmonary edema induced by dinitrogen tetroxide

作　　者：叶明亮[1] 吴海寰 夏亚东[1] 闻思真[1] 郭绪益 彭立义 

机构地区：[1]军事医学科学院毒物药物研究所

出　　处：《军事医学科学院院刊》1996年第4期290-293,共4页Bulletin of the Academy of Military Medical Sciences

摘　　要：首次提出改进型静式吸入中毒方法——大体积布毒，采用固定间隔时间、多次小体积补充毒剂的方法，并以此建立大鼠四氧化二氮急性肺水肿模型。研究表明：在３０ｍｉｎ吸入中毒期间，中毒浓度具有良好的浓度稳定性；通过肺重系数的测定及肺脏病理组织学观察证实，该急性肺水肿模型是成功的。The improved static inhalation exposure method, i. e. exposure by large dose first and small dose many times in fixed interval period,was advanced for the first time and a rat model of acute pulmonary edema was reconstructed induced by dinitrogen tetroxide. The results showed that the exposure concentrations were very stable within 30 min inhalation exposure period. The results that the increase of lung weight coefficient and the pathological changes in rats showed that the rat model of acute pulmonary edema was successful.

关 键 词：气体中毒 肺水肿 四氧化二氮 

分 类 号：R595.102[医药卫生—内科学] R541.630.2[医药卫生—临床医学]