银杏叶提取物联合甲钴胺治疗糖尿病周围神经病变疗效观察  

Observation on effect of extract of gingko biloba combined with mecobalamin on diabetic peripheral neuropathy.

作　　者：陈杭军[1] 余毅[1] 孙晓玲[1] 

机构地区：[1]东莞市人民医院综合科,广东东莞523018

出　　处：《中国热带医学》2006年第9期1650-1651,共2页China Tropical Medicine

摘　　要：目的观察银杏叶提取物(Extractsofginkgobiloba,EGB)与甲钴胺联合治疗糖尿病周围神经病变(Diabeticperipheralneuropathy,DPN)的疗效。方法选择2型糖尿病并伴有不同程度周围神经病变临床症状患者88例,随机分为两组,治疗组46例,予银杏叶提取物(舒血宁)25ml加入0.9%氯化钠溶液250ml静脉滴注,每天1次,同时予甲钴胺500μg肌肉注射,每天1次,对照组42例,单用甲钴胺500μg肌肉注射,每天1次,连续治疗4wk。观察两组患者治疗前后症状、体征和神经生理学指标。结果治疗组症状、体征明显改善(P<0.01),神经传导速度明显增加(P<0.01)具有显著性差异;对照组在神经症状、体征及神经传导速度方面也有改善(P<0.05)。结论银杏叶提取物与甲钴胺联用治疗糖尿病周围神经病变比单用甲钴胺疗效更好。Objective To observe the curative effect of extracts of gingko biloba combined with mecobalamin on diabetic peripheral neuropathy. Methods 88 patients were divided into treatment group consisted of 46 cases intravenously given extracts of gingko biloba 25 ml added with 0.9% sodium chloride 250 ml q.d. VD. in combination with mecobalamin 500μg q.d. im. at the same time for 4 weeks and the control group consisted of 42 cases intramuscularly given mecobalamin alone with the same dosage as that for the treatment group. The results were observed. Results The symptoms and sings in the treatment group and the control group were significantly improved （ P 〈 0.05 and P 〈 0.01）, the speed of nerve conduction was also sigrfificantly increased （ P 〈 0.05 and P 〈 0.01 ）. Conclusion The curative effect of extracts of gingko biloha combined with mecobalamin on the diabetic peripheral neuropathy is better than that of Mecobalamin alone.

关 键 词：银杏叶提取物 甲钴胺 糖尿病 

分 类 号：R587.1[医药卫生—内分泌]