^(99)Tc^m-N-NOET脑显像在颅内占位病变鉴别诊断中的应用  

Diagnostic value of ^(99)Tc^m-N-NOET imaging for intracranial occupying lesion

作　　者：张莺[1] 刘建中[1] 李思进[1] 范毅民[2] 张薇[1] 胡光[1] 

机构地区：[1]山西医科大学第一医院核医学科,太原030001 [2]山西医科大学第一医院神经外科,太原030001

出　　处：《核技术》2006年第9期694-697,共4页Nuclear Techniques

摘　　要：将24例术前CT和或MRI发现颅内占位病变的患者进行了99Tcm-N-NOET脑显像,其中20例在次日进行了99Tcm-MIBI对照检查。所有患者于显像后2周内进行了手术。静脉注射显像剂后30min和2h采集图像,将显像结果进行4分法评分及计算机半定量分析计算肿瘤组织计数与正常脑组织比值(T/N)即摄取比值。两种显像剂在判断病变良恶性方面均有统计学差异,但二者之间无统计学差异。99Tcm-N-NOET可以通过血脑屏障,故它在脑肿瘤中的聚集不依赖于血脑屏障的破坏;肿瘤细胞增殖活跃的颅内病变可以聚集99Tcm-N-NOET,有助于对脑肿瘤治疗方式的选择和对预后估计;在颅内占位良性病变中,99Tcm-N-NOET很少有浓聚。The objectives of this study are to estimate the utility of NOET in the diagnosis of intracranial occupying lesion and to compare the detectability of NOET and MIBI and the relationship with histopathology. 24 patients with untreated intracranial occupying lesion contfirmed by CT and/or MRI were included in this study. 20 of them underwent MIBI imaging also. All patients were operated during 2 weeks after imaging. Statistical significance was observed for both agents in differentiating intracranial occupying lesions, but no statistical significance between them. These preliminary results indicate that NOET can go through blood brain barrier and be concentrated on malignant lesions, but it is few concentrated on benign lesions and the false positive cases are less than MIBI. So it may be a more suitable new tumor positive agent.

关 键 词：^99Tc^m-N-NOET ^99TC^M-MIBI 脑肿瘤 放射性核素显像 

分 类 号：R817.4[医药卫生—影像医学与核医学]