Fcγ受体ⅡA基因多态性与冠心病和扩张型心肌病的关系  

Genetic Polymorphism of FcγRⅡA-Genes in Patients with Coronary Heart Disease and Dilated Cardiomyopathy

作　　者：姜红[1] 杜明[2] 西雁[1] 唐斌[1] 葛均波[1] 

机构地区：[1]复旦大学中山医院上海心血管疾病研究所,上海200032 [2]复旦大学妇产医院,上海200011

出　　处：《国际遗传学杂志》2006年第4期246-248,259,共4页International Journal of Genetics

摘　　要：目的炎症和免疫机制参与冠心病(CHD)和扩张型心肌病(DCM)的心肌损害。免疫球蛋白Fc受体(FcR)家族的FcγRⅡ参与免疫球蛋白介导的损伤过程,且与C反应蛋白结合,在炎症和免疫损害中起重要作用。有报道显示FcγRⅡ编码氨基酸131位置上的组氨酸(H/H)和精氨酸(R/R)多态性与某些炎症性和自身免疫性疾病有关。本研究旨在探讨该多态性与CHD和DCM的关系。方法正常对照组199名,冠脉造影证实的CHD患者324名,DCM患者116名,采用PCR和变性高效液相色谱仪分析(DHPLC)研究基因多态性。结果①按显性效应遗传模型分析(HH+HR与RR),DCM患者FcγRⅡA的H显性效应频率为0．92,较对照组0．78明显增高(P＜0．001)；②按加性效应遗传模型(HH与RR和HR与RR),DCM患者H加性效应频率也明显高于对照组(P＜0．01和P＜0．001)；③DCM患者和对照组H等位基因频率分别为0．63和0．55,有显著性差异(P＜0．05)。而CHD患者与对照组基因频率无显著差异。结论H等位基因可能是DCM患者的易感基因,但并不是冠心病的易感基因。Objective To determine whether the polymorphism of FcγR Ⅱ A-Genes influences the risk of CHD and DCM. Methods The studied population consisted of 199 controls, 324 patients with angiographically documented CHD, and 116 patients with DCM. All subjects were genotyped by polymerase chain reaction and analyzed by denaturing high-performance liquid chromatography （DHPLC）. Results ①Analysis of the genotype with respect to dominant effects of the H allele（HH ＋ HR vs. RR） was 0.92 and 0.78 ,the individuals with the H allele had a significantly increased risk of DCM（P 〈0. 001 ） ;②Additive effects of the H allele （HH vs. RR and HR vs. RR）showed that also the individuals with the H allele had a significantly increased risk of DCM （P 〈0. 01 and P 〈0. 001 ） ; ③The H Allele frequencies of FcγR v A were 0.63 in the patients with DCM differing from those in the control subjects, which were 0.55 （ P 〈 0. 05 ）, whereas no significant differences were observed between controls and CHD patients. Conclusion Our findings suggest that individuals with the H allele had a significantly increased risk of DCM, but not CHD.

关 键 词：FCΓ RⅡA基因 多态性 冠心病 扩张型心肌病 

分 类 号：R541.4[医药卫生—心血管疾病]