五步蛇毒的血管紧张素转换酶抑制剂与卡托普利对大鼠高血压的影响  

THE EFFECTS OF A NEW ANGIOTENSIN-COVERTINGENZYMEINHIBITOR(Ai93)AND CAPTOPRIL ON THE BLOOD PRESSURE OF HYPERTENSIVC RATS

作　　者：刘绵林[1] 舒雨雁[1] 

机构地区：[1]广西医科大学蛇毒研究所

出　　处：《广西医科大学学报》1996年第2期4-7,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金

摘　　要：用来自中国五步蛇毒（ＶｅｎｏｍｏｆＡｇｋｉｓｔｒｏｄｏｎａｃｕｔｕｓ）的新ＡＣＥＩ（ＡＩ９３）与卡托普利，在麻醉大鼠体内进行抑制ＡｎｇＩ和对抗大鼠２Ｋ—ＩＣ型急性肾性高血压的作用效应比较。结果ＡＩ９３在体外对ＡＣＥ的抑制虽较弱（１１．０μｍｏｌ／Ｌ），但在体内效应却较强。８０μｇ／ｋｇ的ＡＩ９３和卡托普利在大鼠体内抑制ＡｎｇＩ和抗急性肾性高血压已有显著意义。ＡＩ９３在２０～１８０μｇ／ｋｇ的范围内抑制ＡｎｇＩ的量—效对数回归分析呈正比；在相同条件下用同一剂量的卡托普利作比较，它们的作用功能和反应程度却不一致，卡托普利对肾性高血压有更强的效应，且量一效对数回归不呈正比。A new angiotensin-converting engyme inhibitors(AI93)from the venom of agk-istrodOn acutus and captopril were compared for their efficacy in hypertensive rats caused by in-jecting ang I and 2K- 1C medel.The activity of AI93 was higher in vivo than in vitro.The injec-tions of 80μg/kg of AI93 and captopril could antagonize the hypertension caused by 2.5μg/kgAng I and the hypertension 2K-1C model,P<0.05.With doses with in 20～180μg/ks AI93 hadpositive dose-effect relationship in analytic logarithmic regression,while captoprll did not showsuch relatiOnship.But captopril was more effective against the hypertension in 2K-1C model.

关 键 词：高血压 蛇毒 血管紧张素酶 抑制剂 卡托普利 

分 类 号：R544.105[医药卫生—心血管疾病]