泛昔洛韦在NaOH修饰玻碳电极上的伏安行为及测定  

Study of the Voltammetric Behaviours of Famciclovir at a NaOH-modified Glassy Carbon Electrode and Its Practical Analytical Application

作　　者：李春哲[1] 李海南[2] 朴栋海 王桂芬[1] 

机构地区：[1]延边大学理学院化学系,吉林延吉133002 [2]淮海工学院海洋学院,江苏连云港222005 [3]吉林省水环境监测中心延边分中心,吉林延吉133001

出　　处：《分析测试学报》2006年第5期102-105,共4页Journal of Instrumental Analysis

摘　　要：采用循环伏安法（CV）和微分脉冲溶出伏安法（DPSV）对抗病毒药泛昔洛韦（FCV）在NaOH修饰电极上的阳极溶出伏安行为进行了研究。在pH=3．0的Britton—Robinson（B—R）缓冲底液中，泛昔洛韦在＋1．24V有一良好的氧化峰，线性范围为8～100μmol／L，检出限为0．52μmol／L，对实际样品进行了测定，并对泛昔洛韦的电极反应机理作了探讨。The voltammetric property of famciclovir was studied by cyclic voltammetry and differential pulse anodic stripping voltammetry at a NaOH-modified glassy carbon electrode. An oxidative peak of famciclovir was obtained by cyclic vohammetry in pH 3 B - R buffer solution, and the peak potential was at ＋ 1.24 V. The peak current was linear to the concentration of famciclovir ranging from 8 - 100μmol/L and the detection limit was 0. 52μmol/L. The determination of famciclovir has been performed and the reaction mechanism of electrochemical oxidation of famciclovir at the modified electrode has been studied too.

关 键 词：泛昔洛韦 修饰电极 循环伏安法 微分脉冲溶出伏安法 反应机理 

分 类 号：O657.14[理学—分析化学] R978.7[理学—化学]