姜黄素类似物的合成及其清除自由基的研究  

Synthesis and free radical scavenging abilities of curcumin analogs

作　　者：邓兵[1] 杜志云[2] 唐煌[3] 古练权[3] 

机构地区：[1]达州职业技术学院,四川达州635001 [2]广东工业大学轻工化工学院,广东广州510090 [3]中山大学药学院,广东广州5100980

出　　处：《化学研究与应用》2006年第9期1124-1126,共3页Chemical Research and Application

基　　金：国家自然科学基金(20032021)资助项目

摘　　要：Curcumin is the main component of Curcuma longa,a traditional Chinese medicinal herb,with excellent antioxidant.Curcumin is easily decomposed under light and heat.In this study,to find stable antioxidants,6 curcumin analogs(A1-6) were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCl catalysis,and the free radical（DPPH） scavenging abilities of synthetic curcumin analogs were evaluated.The results showed that the free radical（DPPH） scavenging abilities of curcumin analogs（A2,A3 and A6） were promoted when hydroxyl or methoxyl groups were introduced in the ortho place of phenols,the compound with ortho dihydroxy groups showed the stronges free radical（DPPH） scavenging abilities among curcumin analogs with IC50 of 1.5 μM.Curcumin is the main component of Curcuma longa, a traditional Chinese medicinal herb, with excellent antioxidant. Curcumin is easily decomposed under light and heat. In this study ,to find stable antioxidants,6 curcumin analogs （A1-6 ） were synthesized by coupling the appropriate aromatic aldehyde and cyclohexanon with HCI catalysis, and the free radical （DPPH） scavenging abilities of synthetic curcumin analogs were evaluated. The results showed that the free radical （DPPH） scavenging abilities of curcumin analogs （ A2, A3 and A6 ） were promoted when hydroxyl or methoxyl groups were introduced in the ortho place of phenols, the compound with ortho dihydroxy groups showed the stronges free radical （DPPH） scavenging abilities among curcumin analogs with IC50 of 1.5μM.

关 键 词：姜黄素类似物 抗自由基 DPPH 合成 

分 类 号：O629.5[理学—有机化学]