金钱对唑合剂防治胆石症的实验研究  

Experimental Research on Jinqianduizuo Mixture Preventing and Treating Cholelithiasis

作　　者：周大兴[1] 将志炕 阮叶萍[1] 葛蕾[1] 朱晓燕[1] 顾静[1] 王晶[1] 

机构地区：[1]浙江中医药大学药学院,杭州310053 [2]浙江省杭州市萧山区第六人民医院

出　　处：《浙江中医药大学学报》2006年第5期530-532,共3页Journal of Zhejiang Chinese Medical University

摘　　要：目的观察中药经验方金钱对唑合剂对胆色素结石的预防与治疗作用,为胆石症的治疗提供依据。方法采用豚鼠胆色素结石模型,观察胆囊形状、成石率、胆汁量,并进行胆汁和血清的生化测定。结果金钱对唑合剂三剂量组与模型组比较,胆囊成石率、胆汁量、总胆红素含量、总胆汁酸含量有显著性差异,而直接胆红素含量和总胆固醇、甘油三酯、高密度脂蛋白的含量差异无显著意义。结论表明金钱对唑合剂能显著降低豚鼠胆结石的发生率;能明显促进豚鼠胆汁的分泌;有调节胆汁成分的作用;但对血脂成分无明显的影响。[Objective] To observe the preventative and therapeutical effect on bile pigment calculus of Jinqianduizuo Mixture which is a traditional Chinese medicine empirical formula and provide foundation for the therapy of cholelithiasis, [Method] Using the model of bile pigment calculus in guinea pigs. Observing the gall bladder＇s shape,the rate of forming gallstone and the total bile. Then making biochemical determination of the bile and the blood serum. [Result] There are significant differences between model control group and three treated groups of Jinqianduizuo Mixture in the rate of forming gallstone,the bilious quantity, the contents of total bilirubin and total bile acids. While in the contents of direct bilirubin, total cholesterol,triglycerides and high-density lipoproteins,they have no significant difference. [Conclusion]The results indicate that Jinqianduizuo Mixture can conspicuously cut down the gallstone＇s incidence of guinea pigs and can obviously promote the bilious externalization in guinea pigs. It also can promote bile secretion distinctly,but have no evident effect on the ingredients of blood-lipid.

关 键 词：金钱对唑合剂 胆结石 胆汁 

分 类 号：R285.6[医药卫生—中药学]