711例男性不育症患者血细胞遗传学分析  

Cytogenetic analysis in 711 infertile men

作　　者：金昱[1] 王晓华[1] 翁炳焕[1] 

机构地区：[1]浙江大学医学院附属妇产科医院检验科,浙江杭州310006

出　　处：《全科医学临床与教育》2006年第5期379-381,共3页Clinical Education of General Practice

摘　　要：目的分析男性不育症患者细胞遗传学特点,为临床治疗提供理论依据。方法取711例临床确诊男性不育患者的外周血,经淋巴细胞培养、制片及G显带后,作常规染色体核型分析。结果711例男性不育患者中发现染色体异常147例,异常率为20.68%(147/711),其中性染色体异常122例,占异常核型82.99%(122/147);常染色体结构异常25例,占异常核型17.01%(25/147)。结论染色体核型异常在男性不育患者中占有较高的比例,细胞遗传学分析是男性不育患者临床诊治中不可缺少的检验项目。Objective To find out the cytogenetic traits on infertile man. Methods Karyotypes of 711 infertile men were performed on peripheral blood lymphocytes according to standard methods and analyzed by chromosome G banding. Result Chromosome abnormalities in 711 infertile men were 20.68% （147/711）, including 122 cases of sex chromosomal aberrations and 25 cases of autosomal chromosomal aberrations. Conclusions The high rate of chromosomal anomalism in infertile men was obtained, it may be suggested that cytogenetic analysis is a prior test in clinical treatment of infertile men.

关 键 词：男性不育 细胞遗传学 染色体异常核型 

分 类 号：R698.2[医药卫生—泌尿科学]