(E)-α-氧代环十二酮肟醚的合成及其杀菌活性(英文)  

Synthesis and Fungicidal Activities of (E)-α-Oxocyclododecanone Oxime Ethers

作　　者：李明磊[1] 梁晓梅[1] 覃兆海[1] 王道全[1] 

机构地区：[1]农业部农药化学及应用技术重点开放实验室中国农业大学应用化学系,北京100094

出　　处：《农药学学报》2006年第3期209-213,共5页Chinese Journal of Pesticide Science

基　　金：Supported by the National Basic Research Program of China("973"Plan)(2003CB114407).

摘　　要：由环十二酮先后经肟化和醚化反应合成了一系列（E）-α-氧代环十二酮肟醚，收率59％～92％。其结构经IR，^1H NMR，^13CNMR确证。以化合物50为代表，通过单晶X-衍射分析确证了其构型为E式。生物测定结果表明，多数化合物对蔬菜苗期立枯病菌、黄瓜黑星病菌、黄瓜炭疽病菌、瓜类灰霉病菌，棉花枯萎病菌和芦笋茎枯病菌的生长有良好的抑制活性。如5k对上述6种病原菌的EC50值分别为13、9、12、19、14、3mg/L。A series of （E）-α-oxocyclododecanone oxime ethers （5） were synthesized by oximation of cyclododecanone followed by etherification in yields of 59% - 92%. Their structures were confirmed by IR, ^1H NMR, ^13C NMR and elemental analysis. The （E）-configuration was confirmed by single crystal X-ray diffraction analysis of a representative compound （5o）. Bioassay results showed that most of the title compounds present good fungicidal activities against Rhizoctonia solani, Cladosporium cucumerinum, Colletotrichum orbiculare, Botrytis cinerea, Fusarium oxysporum and Phomopsis asparagi. For example, the EC50 values of 5k against mentioned-above six fungi were 13,9,12,19, 14.3 mg/L. resoectivelv.

关 键 词：(E)-α-氧代环十二酮肟醚 合成 构型 杀菌活性 

分 类 号：O623.542[理学—有机化学]