Aβ显像剂^(99)Tc^m-MAMA-DMABP的合成及生物分布  

Synthesis and Biodistribution of ^(99)Tc^(m)-MAMA-DMABP as β-Amyloid Imaging Agent

作　　者：王武尚[1] 陈祥纪[1] 刘伯里[1] 

机构地区：[1]北京师范大学化学系

出　　处：《核化学与放射化学》2006年第3期157-162,共6页Journal of Nuclear and Radiochemistry

基　　金：国家自然科学基金资助项目(20471011)

摘　　要：制备了新的Aβ斑块显像剂99Tcm-酰胺基氨基二硫醇(MAMA)-4-氨基-4′-二甲氨基联苯(DMABP),并研究了其在正常小鼠体内的生物分布。实验结果表明,99Tcm-MAMA-DMABP具有较高的初始脑摄取,较快的正常脑组织清除,尾静脉注射后2 min的脑摄取达0.88%/g,2 min与60 min的脑摄取率比值为2.8。Alzheimer＇s disease （AD） is a neurodegenerative disease of the brain. Radioactive imaging agents for β-amyloid plaques in the brain will be useful in early noninvasive diagnosis and monitoring the progression of the disease. A new imaging agent for β-amyloid plaques, ^99Tcm-MAMA-DMABP was prepared, and its biodistribution in normal mice was studied. The results indicate that ^99Tcm-MAMA-DMABP has fairly high initial brain uptake and fast brain clearance in normal mice. Brain uptake is 0. 88%/g at 2 min post i.v. injection. Brain uptake ratio （2 min/60 min） is 2.8.

关 键 词：阿尔茨海默病 ^99TC^M Β-淀粉样蛋白 斑块 

分 类 号：O614.712[理学—无机化学]