代谢显像剂3’-脱氧-3’-^(18)F-氟代胸腺嘧啶核苷的自动化合成  

Automated Synthesis of 3'-Deoxy-3'-Fluorothymidine as Metabolize Imaging Agent

作　　者：赵书强[1] 滕学朋 杨国仁[1] 陈鲁生[1] 

机构地区：[1]山东省肿瘤防治研究院,山东济南250117

出　　处：《核化学与放射化学》2006年第3期174-177,共4页Journal of Nuclear and Radiochemistry

摘　　要：为了制备3’-脱氧-3’-18F-氟代胸腺嘧啶核苷(18F-FLT),使用自动化合成装置Tracerlab FXF-N和BAThy法。以5’-O-苯甲酰基-2,3-脱水-胸腺嘧啶脱氧核苷(BAThy)为前体,经过氟化、水解两步反应制得3’-脱氧-3’1-8F-氟代胸腺嘧啶核苷(18F-FLT)注射液。合成总时间约50 min,放化产率约10%,放化纯度大于95%。整个合成过程自动化完成,操作简单、灵活。3＇-Deoxy-3 ＇-Fluorothymidine （^18 F-FLT） is synthesized by ＂BAThy＂ method at Tracerlab FXF-N system. By using 5＇-O-benzoyl-2,3-anhydro-thymidine（BAThy） as the precursor, ^18F-FLT is obtained by two step reactions, including the nucleophilic fluoration and hydrolysis. The synthesis can be completed about 50 min. The radiochemical yield and radio- chemical purity are about 10% and 95%, respectively. The procedure is guide simple and automated synthesis.

关 键 词：^18F—FLT 代谢显像剂 自动化合成 

分 类 号：R817.9[医药卫生—影像医学与核医学]