一种^(99)Tc^m标记的5-HT_(1A)受体显像剂的合成与标记  

Synthesis and Labeled With ^(99)Tc^m of Serotonin(5-HT_(1A)) Receptor Imaging Agent

作　　者：蒋泉福[1] 吴春英[1] 陆春雄[1] 陈正平[1] 王颂佩[1] 张同兴[1] 李晓敏[1] 

机构地区：[1]江苏省原子医学研究所,江苏无锡214063

出　　处：《同位素》2006年第3期150-153,共4页Journal of Isotopes

摘　　要：合成了一种99Tcm标记的5-HT1A受体显像剂。该显像剂先由二硫二氮与6-溴己酰氯结合,再与2-(1-哌嗪)苯甲醚结合,经还原、脱保护反应得到标记前体,再对前体进行99Tcm标记。标记率达90%以上,薄层层析测得标记物放化纯度大于95%。The synthesis and labeled with ^99Tc^m of serotonin（5-HT1A） receptor imaging agent derived from way-100635 are reported. The precursor is synthesized by chlorization of N2S2 and condensation with 2-（1-piperazino）phenol, then reduction and deprotection are carried. The labeling ratio is over 90% and the radiochemical purity is over 95% determined by thin layer chromatography（TLC）.

关 键 词：^99TC^M标记 5-HT1A受体显像剂 合成 

分 类 号：O628.5[理学—有机化学] R817.9[理学—化学]