^3H-RNA示踪法研究大鼠口服核糖核酸后的组织分布  

The Histological Distribution of Ridonucleic Acid Taken Orally by Rat With ^3H-RNA Tracing Technique

作　　者：张洪卫[1] 李怀芬[1] 李恕[2] 刘庆莹[2] 牛惠生[1] 

机构地区：[1]中国医学科学院放射医学研究所,天津300192 [2]大连珍奥集团股份有限公司,辽宁大连116620

出　　处：《同位素》2006年第3期166-168,共3页Journal of Isotopes

摘　　要：利用3H-RNA示踪法研究了大鼠口服核糖核酸(RNA)制剂(80 mg/kg)后0.5、1.0、4.0和10.0 hRNA代谢产物在其脑、甲状腺、胸腺、心、肺、肝,脾、胃、小肠、结肠、肾、睾丸、子宫、肌肉和皮肤组织中的分布,旨在对核酸类生物制品的深度开发提供依据。结果显示,大鼠口服RNA后,其代谢产物在各器官中均有分布,除在胃和肠中含量很高外,在神经、内分泌和免疫相关组织中含量也较高。在给药后10.0 h时RNA代谢产物在组织中仍有一定含量,这表明RNA已被组织利用。The rat histological distribution of ribonucleic acid（RNA） metabolite are detected by ：^3H-RNA radioactive tracing technique. The results indicate that the RNA metabolites are distributed in every organ of the rat after taking orally. The RNA metabolite contents are higher in nervous, endocrine and immune systems in addition to stomach and intestine. The certain amount of RNA metabolite is still maintained in tissues at 10.0 h after taking RNA orally. It indicates that RNA has been used by the tissues.

关 键 词：^3H 核糖核酸(RNA) 组织分布 

分 类 号：Q506[生物学—生物化学] R817.93[医药卫生—影像医学与核医学]