结构新颖的茚取代肟醚类化合物的合成  

Synthesis of novel indene-substituted oxime ether compounds

作　　者：吐松[1] 徐龙鹤[1,2] 于春睿[1,2] 张弘[3] 李志念[3] 刘长波[4] 

机构地区：[1]大连理工大学精细化工国家重点实验室 [2]沈阳化工研究院,沈阳110021 [3]沈阳化工研究院 [4]沈阳药科大学制药工程学院

出　　处：《农药》2006年第10期677-680,共4页Agrochemicals

摘　　要：以邻位卤代苯甲醛和3-丁烯-2-醇为原料通过钯催化“一锅法”反应合成了2-乙酰基茚7a-e,7a-e肟化之后和N-(2-溴甲基苯基)-N-甲氧基氨基甲酸甲酯反应合成了肟醚类氨基甲酸甲酯3a-e,进一步胺解之后得到了肟醚类氨基甲酰甲胺3f-j。共设计合成了10个结构新颖未见文献报道的茚取代肟醚类化合物,其结构经红外、核磁、元素分析确认。2-Acetylindenes 7a-e were synthesized by the reaction of orthohalogenated benzaldehyde with but-3-en-2- ol via one-pot palladium-catalyzed reaction. The intermediate which obtained from oximation of 7a-e reacted with methyl N-（2-bromomethylphenyl）-N-methoxycarbamate to synthesize oxime ether methyl carbamate 3a-e. Then amination of 3a-e produced oxime ether methyl carbamyl amide 3f-j. Ten novel oxime ether compounds were designed and synthesized. Their structures were confirmed by IR, IH NMR and elemental analyses.

关 键 词：钯催化 2-乙酰基茚 肟醚 合成 

分 类 号：TQ455.4[化学工程—农药化工]