熟地黄及其多糖中枢抑制作用研究  

Inhibition Effect of Shu Dihuang and the Polysaccharide on CNS

作　　者：崔豪[1] 冯静[2] 崔瑛[2] 王辉[2] 申秀丽[2] 孙曙光[2] 靖慧军[2] 翟立武[2] 

机构地区：[1]淮滨县卫生学校,河南淮滨464400 [2]河南中医学院,河南郑州450008

出　　处：《河南中医学院学报》2006年第6期18-19,共2页Journal of Henan University of Chinese Medicine

基　　金：河南省高校杰出科研人才创新工程项目(HAIPURT)(编号:2005KYCX006)

摘　　要：目的:研究熟地黄及其多糖的中枢抑制作用。方法:通过小鼠自发活动实验、抗惊厥实验、镇静催眠实验观察熟地黄及其多糖对中枢的抑制作用。结果:熟地黄煎液、熟地黄多糖均能够抑制小鼠的自发活动;缩短阈下剂量戊巴比妥钠诱导的小鼠睡眠潜伏期,延长睡眠时间;延缓异烟肼惊厥的发作潜伏期,减少动物死亡数。结论:熟地黄煎液、熟地黄多糖对中枢神经系统具有抑制作用。Objective： To study the inhibition effect of Shu Dihuang and the Polysaccharide on CNS. Method： By Spontaneous activity test, Pentobarbital ＇sodium hypnogenesis test, Est, anti-seizure test to study the the inhibition effect of Shu Dihuang and the Polysaccharide. Results： Both Shu Di-huang and the Polysaccharide can inhibit Spontaneous activity; can shorten the process of falling into sleep, prolong the sleeping time; shorten the process of eclampsia, reduce the death-rate. Conclusion： Shu Dihuang and the Polysaccharide have the the the inhibition effect on CNS.

关 键 词：熟地黄 熟地黄多糖 中枢抑制 

分 类 号：R285.5[医药卫生—中药学]