肾脏病中不同尿蛋白定量法的临床意义  

CLINICAL SIGNIFICANCE OF MEASURING URINARY PROTEINS QUANTIITIES WITH DIFFERENT QUANTITATIVE METHODS IN PATIENTS WITH RENAL DISEASE

作　　者：卓华钦[1] 吴锡信[2] 

机构地区：[1]东莞市石龙人民医院,广东东莞523321 [2]中山大学附属第五医院,广东珠海519000

出　　处：《现代医院》2006年第10期59-60,共2页Modern Hospitals

摘　　要：目的探讨肾脏病中不同尿蛋白定量法的临床意义。方法分别测量72例门诊患者的24h尿蛋白定量(24hUPQ)、任意一次尿蛋白量、血尿肌酐以及60例门诊患者的血尿β2-微球蛋白,分别求出任意一次尿蛋白量与血尿肌酐的比值、尿蛋白量与血尿β2-微球蛋白的比值,求出各比值与24hUPQ间的相关系数及回归系数,并进行显著性检验,分别列出它们的直线回归方程。用这四条直线回归方程所测算出的24hUPQ与传统方法所测出的24hUPQ进行比较。结果各相关系数及回归系数均具有显著性意义(p均<0.01),直线回归方程成立。用这四条直线回归方程所测算出的24hUPQ与传统方法所测出的24hUPQ间无显著性差异(p均>0.05)。结论用任意一次尿蛋白定量法求得的24hUPQ准确、可靠,可在临床上推广使用。Objective To probe into the clinical significance of different urinary proteins quantitative method in patients with renal disease. Methods 72 case of outpatients were measured of 24 hours urinary protein quantities （24 h UPQ）, anytime a urinary protein quantity, creatinine of blood and urine, β2-microglobulin of blood and urine in 62 case of outpatients. Determined respectively ratio of anytime a protein quantity with creatinine of blood and urine, ratio of urinary protein quantity with creatinine of blood and urine, figured out related and regression coefficient of each ratio and 24 h UPQ, carried through significance test and then list their llne regression equations. Compared 24 h UPQ by line regression equations and conventional measure. Results Each related and regression coefficient is significant （ all p 〈 0. 01 ）, The equations come into ,existence. There were no statistically significant difference between two methods in measuring urinary proteins quantities （ all p 〉 0. 05 ）. Conclusion Getting 24 h UPQ by anytime a quantitative method of urinary proteins is exact and credible ; Itcan be use in clinic.

关 键 词：尿蛋白 肾脏病 肌酐 Β2-微球蛋白 

分 类 号：R692[医药卫生—泌尿科学] R446[医药卫生—外科学]