脑内发现全新的阿片受体样受体及其内源性配体  

The Discover of A Novel Opioid-Receptor-Like Receptor and its Endogenous Ligand

作　　者：方园[1] 韩济生[1] 

机构地区：[1]北京医科大学神经科学研究中心

出　　处：《生理科学进展》1996年第3期210-214,共5页Progress in Physiological Sciences

摘　　要：１９９４年克隆了一种孤儿受体──阿片受体样（ＯＲＬ）受体。１９９５年又发现其内源性配体ＯＦＱ（试译：孤啡肽）或Ｎｏｃｉｃｅｐｔｉｎ（以试译：痛敏肽）。ＯＲＬ受体与已知的阿片受体有５０％同源性，ＯＦＱ则与强啡肽Ａ化学结构高度相似，这两系统在功能上可能既有相反的作用，又有相似的作用，其详情正在研究中。A novel member of the opioid receptor family(orphan ORL receptor)was cloned in 1994,followed by the discovery of its endogenous ligand OFQ or nociceptin in 1995.ORL receptor has 50%homology with conventional opioid receptor,and OFQ is structurally homologous with dynorphin A.Whether the two systems are functionally antagonistic or synergistic with each other is a subject of future research.

关 键 词：脑 阿片受体样 受体 孤啡肽 内源性配体 

分 类 号：R338[医药卫生—人体生理学]